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NDUFAF4 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5689124
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4, NDUF4_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O00217 NDUFS8
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
NDUFAF4 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P032 NDUFAF4
Gene Names
NDUFAF4, C6orf66, HRPAP20, HSPC125, My013
Chain
initiator methionine:, chain:2-175
Reference Genes
BioGPS Gene:29078 NDUFAF4
COSMIC (genes):NDUFAF4 NDUFAF4
CTD Gene:29078 NDUFAF4
dbSNP Gene:29078 NDUFAF4
ENSEMBL:ENSG00000123545 NDUFAF4
ENSEMBL_homo_sapiens_GENE:ENSG00000123545.6 NDUFAF4
HGNC:21034 NDUFAF4
KEGG Gene (Homo sapiens):29078 NDUFAF4
Monarch:29078 NDUFAF4
NCBI Gene:29078 NDUFAF4
OMIM:611776 NDUFAF4
UCSC:Q9P032 NDUFAF4
Reference Transcript
RefSeq:NM_014165.3 NDUFAF4
Other Identifiers
11720191_s_at
11720192_at
11720193_x_at
219006_PM_at
219006_at
227559_PM_at
227559_at
29078
2965675
2965676
2965677
2965678
2965681
2965686
2965687
43987_at
53035_at
53605_at
8128322
A_24_P171983
A_24_P46659
GE58562
GO:0005515
GO:0005516
GO:0005739
GO:0005743
GO:0005829
GO:0007005
GO:0008284
GO:0010257
GO:0012501
GO:0016020
GO:0031966
GO:0032981
GO:0043066
GO:0043226
GO:0051607
GO:0065003
GO:0098542
HMNXSV003038731
Hs.5232.1.A1_3p_at
ILMN_1659524
ILMN_2205350
PH_hs_0026725
TC06001956.hg
g7661785_3p_at
g7661785_3p_x_at
Participates
as an input of
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
as an output of
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
as a component of
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
Inferred To
NDUFAF4 [mitochondrial inner membrane]
(Bos taurus)
NDUFAF4 [mitochondrial inner membrane]
(Caenorhabditis elegans)
NDUFAF4 [mitochondrial inner membrane]
(Canis familiaris)
NDUFAF4 [mitochondrial inner membrane]
(Drosophila melanogaster)
NDUFAF4 [mitochondrial inner membrane]
(Gallus gallus)
NDUFAF4 [mitochondrial inner membrane]
(Sus scrofa)
Ndufaf4 [mitochondrial inner membrane]
(Mus musculus)
Ndufaf4 [mitochondrial inner membrane]
(Rattus norvegicus)
Ghost homologue of NDUFAF4 [mitochondrial inner membrane]
(Danio rerio)
ndufaf4 [mitochondrial inner membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_054884.1
OpenTargets
ENSG00000123545
GeneCards
Q9P032
HPA
ENSG00000123545-NDUFAF4
Ensembl
ENSG00000123545
,
ENSP00000358272
,
ENST00000316149
PRO
Q9P032
Pharos - Targets
Q9P032
Orphanet
17664
HMDB Protein
HMDBP08888
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BU61 NDUFAF3
1
NDUFAF3 [mitochondrial inner membrane]
(R-HSA-5689126)
0.85
12
UniProt:O75251 NDUFS7
1
NDUFS7 [mitochondrial matrix]
(R-HSA-6788521)
0.725
9
UniProt:Q9P0J0 NDUFA13
8
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
NDUFA13(41-49) [mitochondrial inner membrane]
(R-HSA-9839958)
NDUFA13(100-108) [mitochondrial inner membrane]
(R-HSA-9839959)
NDUFA13(109-144) [mitochondrial inner membrane]
(R-HSA-9839968)
NDUFA13(2-19) [mitochondrial inner membrane]
(R-HSA-9839966)
NDUFA13(69-99) [mitochondrial inner membrane]
(R-HSA-9839964)
NDUFA13(20-40) [mitochondrial inner membrane]
(R-HSA-9839963)
NDUFA13(50-68) [mitochondrial inner membrane]
(R-HSA-9839961)
0.725
6
UniProt:Q9BU61-2 NDUFAF3
0.718
8
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.643
4
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.643
10
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.643
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q9H845 ACAD9
1
ACAD9 [mitochondrial inner membrane]
(R-HSA-5689049)
0.527
5
UniProt:O75306 NDUFS2
1
NDUFS2 [mitochondrial matrix]
(R-HSA-6788520)
0.527
5
UniProt:O95298 NDUFC2
3
NDUFC2 [plasma membrane]
(R-HSA-6806276)
NDUFC2 [azurophil granule membrane]
(R-HSA-6799211)
NDUFC2 [mitochondrial inner membrane]
(R-HSA-59860)
0.527
3
UniProt:O00217 NDUFS8
1
NDUFS8 [mitochondrial matrix]
(R-HSA-6788526)
0.527
5
UniProt:O43674 NDUFB5
1
NDUFB5 [mitochondrial inner membrane]
(R-HSA-163944)
0.527
4
UniProt:Q16718 NDUFA5
2
NDUFA5 [endoplasmic reticulum membrane]
(R-HSA-9714749)
NDUFA5 [mitochondrial inner membrane]
(R-HSA-60599)
0.527
4
UniProt:Q9Y375 NDUFAF1
1
NDUFAF1 [mitochondrial inner membrane]
(R-HSA-5689050)
0.527
4
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
3
UniProt:Q9H7D7 WDR26
1
WDR26 [cytosol]
(R-HSA-9861584)
0.508
2
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