Reactome | RNF40 [nucleoplasm]

RNF40 [nucleoplasm]

Stable Identifier

R-HSA-5689015

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase BRE1B, BRE1B_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75150 RNF40

Gene Names

RNF40, BRE1B, KIAA0661

Chain

chain:1-1001

Reference Genes

BioGPS Gene:9810 RNF40

COSMIC (genes):RNF40 RNF40

CTD Gene:9810 RNF40

dbSNP Gene:9810 RNF40

ENSEMBL:ENSG00000103549 RNF40

HGNC:16867 RNF40

Monarch:9810 RNF40

NCBI Gene:9810 RNF40

OMIM:607700 RNF40

UCSC:O75150 RNF40

Reference Transcript

Other Identifiers

11716158_a_at

11716159_a_at

11750112_a_at

11758742_x_at

16818034

206845_PM_s_at

206845_s_at

239801_PM_at

239801_at

35768_at

3656556

3656557

3656558

3656559

3656560

3656562

3656563

3656564

3656565

3656566

3656567

3656568

3656569

3656570

3656571

3656572

3656573

3656574

3656575

3656576

3656577

3656578

3656579

3656580

3656581

3656582

3656583

3656584

3656586

3656587

3656588

3656589

3656590

3656591

3656592

3656593

3656594

3656595

3656596

3656597

57310_at

62272_at

7994939

9810

A_14_P115362

A_23_P364890

GE53371

GO:0000151

GO:0003723

GO:0003730

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006355

GO:0006511

GO:0016020

GO:0016567

GO:0016740

GO:0031625

GO:0033503

GO:0042803

GO:0043005

GO:0043226

GO:0045944

GO:0046872

GO:0061630

GO:0140096

HMNXSV003026195

Hs.164452.0.A1_3p_at

ILMN_1754669

ILMN_1808712

PH_hs_0028933

PH_hs_0035030

TC16000358.hg

g7662229_3p_s_at

Participates

as a component of

RNF20:RNF40 [nucleoplasm] (Homo sapiens)

Inferred To

bre1 [nucleoplasm] (Dictyostelium discoideum)

Rnf40 [nucleoplasm] (Mus musculus)

Rnf40 [nucleoplasm] (Rattus norvegicus)

BRE1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of RNF40 [nucleoplasm] (Gallus gallus)

RNF40 [nucleoplasm] (Bos taurus)

RNF40 [nucleoplasm] (Canis familiaris)

RNF40 [nucleoplasm] (Sus scrofa)

rfp-1 [nucleoplasm] (Caenorhabditis elegans)

Bre1 [nucleoplasm] (Drosophila melanogaster)

brl2 [nucleoplasm] (Schizosaccharomyces pombe)

rnf40 [nucleoplasm] (Danio rerio)

rnf40 [nucleoplasm] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000357890, ENST00000324685, ENSP00000325677, ENSP00000350563

OpenTargets

ENSG00000103549

IntEnz

2.3.2.27

HPA

ENSG00000103549-RNF40

PRO

O75150

Pharos - Targets

O75150

GlyGen

O75150

PDB

8GUJ, 8IEJ, 8GUI

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.743	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	12
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.547	2
UniProt:Q9BTA9 WAC	1	WAC [nucleoplasm] (R-HSA-8942150)	0.527	3
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.508	3
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2

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