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SHPRH [nucleoplasm]
Stable Identifier
R-HSA-5689010
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase SHPRH ecNumber3.6.4.-/ecNumber ecNumber6.3.2.-/ecNumber, SHPRH_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q96GS4%20BORC6
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
SHPRH [nucleoplasm] (Homo sapiens)
SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
SHPRH [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q149N8 SHPRH
Gene Names
SHPRH, KIAA2023
Chain
chain:1-1683
Reference Genes
BioGPS Gene:257218 SHPRH
COSMIC (genes):SHPRH SHPRH
CTD Gene:257218 SHPRH
dbSNP Gene:257218 SHPRH
ENSEMBL:ENSG00000146414 SHPRH
ENSEMBL_homo_sapiens_GENE:ENSG00000146414.17 SHPRH
HGNC:19336 SHPRH
KEGG Gene (Homo sapiens):257218 SHPRH
Monarch:257218 SHPRH
NCBI Gene:257218 SHPRH
OMIM:608048 SHPRH
UCSC:Q149N8 SHPRH
Reference Transcript
RefSeq:NM_001042683.2 SHPRH
RefSeq:NM_173082.3 SHPRH
RefSeq:XM_006715441.3 SHPRH
Other Identifiers
11722754_a_at
11722755_a_at
11745702_a_at
17024452
226366_PM_at
226366_at
257218
2978070
2978071
2978072
2978073
2978074
2978076
2978081
2978082
2978084
2978090
2978091
2978092
2978093
2978095
2978097
2978099
2978100
2978101
2978102
2978103
2978105
2978106
2978109
2978111
2978112
2978113
2978114
2978116
2978118
2978119
2978120
2978121
2978122
2978123
2978124
2978125
2978126
2978127
2978129
2978130
2978131
2978132
2978133
2978134
2978135
2978138
2978140
45212_at
70197_s_at
71324_at
72753_at
8130038
87229_at
A_23_P337790
A_24_P153576
A_33_P3216083
GE472233
GE488762
GO:0000166
GO:0000209
GO:0000786
GO:0003677
GO:0003824
GO:0004386
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006325
GO:0006334
GO:0006974
GO:0016567
GO:0016740
GO:0016787
GO:0031625
GO:0036211
GO:0043226
GO:0046872
GO:0061630
GO:0065003
GO:0140096
GO:0140097
GO:0140657
GO:0140658
HMNXSV003042198
HMNXSV003045395
Hs.42892.0.A1_3p_at
ILMN_1722423
ILMN_2387303
PH_hs_0022953
TC06002197.hg
Participates
as an input of
SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)
as an output of
SHPRH polyubiquitinates monoubiquitinated PCNA (Homo sapiens)
as a component of
SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] (Homo sapiens)
Inferred To
Shprh [nucleoplasm]
(Rattus norvegicus)
shprh [nucleoplasm]
(Xenopus tropicalis)
SHPRH [nucleoplasm]
(Bos taurus)
SHPRH [nucleoplasm]
(Caenorhabditis elegans)
SHPRH [nucleoplasm]
(Canis familiaris)
SHPRH [nucleoplasm]
(Dictyostelium discoideum)
SHPRH [nucleoplasm]
(Gallus gallus)
SHPRH [nucleoplasm]
(Mus musculus)
SHPRH [nucleoplasm]
(Schizosaccharomyces pombe)
SHPRH [nucleoplasm]
(Sus scrofa)
Dmel\CG7376 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of SHPRH [nucleoplasm]
(Danio rerio)
Ghost homologue of SHPRH [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of SHPRH [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001036148.2
,
XP_006715504.1
,
NP_775105.1
OpenTargets
ENSG00000146414
IntEnz
2.3.2.27
GeneCards
Q149N8
HPA
ENSG00000146414-SHPRH
Ensembl
ENSP00000356475
,
ENSP00000412797
,
ENST00000367505
,
ENST00000275233
,
ENST00000438092
,
ENSP00000275233
,
ENST00000519632
,
ENSP00000430528
,
ENSG00000146414
PRO
Q149N8
Pharos - Targets
Q149N8
PDB
4QN1
,
2M85
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96GS4 BORC6
0.556
3
UniProt:Q8WWZ3 EDARADD
1
EDARADD [cytosol]
(R-HSA-5675659)
0.556
3
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