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TRIM69 [cytosol]
Stable Identifier
R-HSA-5688977
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase TRIM69 ecNumber6.3.2.-/ecNumber, TRI69_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
TRIM69 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86WT6 TRIM69
Gene Names
TRIM69, RNF36, HSD-34, HSD34
Chain
chain:1-500
Reference Genes
BioGPS Gene:140691 TRIM69
COSMIC (genes):TRIM69 TRIM69
CTD Gene:140691 TRIM69
dbSNP Gene:140691 TRIM69
ENSEMBL:ENSG00000185880 TRIM69
HGNC:17857 TRIM69
KEGG:hsa:140691 TRIM69
Monarch:140691 TRIM69
NCBI Gene:140691 TRIM69
OMIM:616017 TRIM69
UCSC:Q86WT6 TRIM69
Reference Transcript
RefSeq:NM_001301144.1 TRIM69
RefSeq:NM_080745.4 TRIM69
RefSeq:NM_001301146.1 TRIM69
RefSeq:NM_182985.4 TRIM69
RefSeq:NM_001301145.1 TRIM69
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
TRIM69 [cytosol]
(Bos taurus)
TRIM69 [cytosol]
(Caenorhabditis elegans)
TRIM69 [cytosol]
(Canis familiaris)
TRIM69 [cytosol]
(Danio rerio)
TRIM69 [cytosol]
(Sus scrofa)
Trim69 [cytosol]
(Mus musculus)
Trim69 [cytosol]
(Rattus norvegicus)
trim69 [cytosol]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000488084
,
ENST00000338264
,
ENSP00000342922
,
ENSG00000278211
,
ENST00000558329
,
ENSP00000479720
,
ENSP00000453332
,
ENSP00000453177
,
ENSP00000488341
,
ENSG00000185880
,
ENST00000329464
,
ENSP00000332284
,
ENSP00000453549
,
ENST00000559390
,
ENST00000631740
,
ENST00000560442
,
ENST00000618398
,
ENST00000633106
OpenTargets
ENSG00000185880
IntEnz
2.3.2.27
GeneCards
TRIM69
HPA
ENSG00000185880-TRIM69
PRO
Q86WT6
Pharos - Targets
Q86WT6
PDB
6YXE
,
4NQJ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08243 ASNS
1
ASNS [cytosol]
(R-HSA-70597)
0.666
4
UniProt:Q15637 SF1
1
SF1 [nucleoplasm]
(R-HSA-8865928)
0.556
3
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