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SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
Stable Identifier
R-HSA-5688566
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
Locations in the PathwayBrowser for interactor UniProt:Q9Y676 MRPS18B
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75396 SEC22B
Gene Names
SEC22B, SEC22L1
Chain
initiator methionine:, chain:2-215
Reference Genes
BioGPS Gene:9554 SEC22B
COSMIC (genes):SEC22B SEC22B
CTD Gene:9554 SEC22B
dbSNP Gene:9554 SEC22B
ENSEMBL:ENSG00000265808 SEC22B
ENSEMBL_homo_sapiens_GENE:ENSG00000265808.4 SEC22B
HGNC:10700 SEC22B
KEGG Gene (Homo sapiens):9554 SEC22B
Monarch:9554 SEC22B
NCBI Gene:9554 SEC22B
OMIM:604029 SEC22B
UCSC:O75396 SEC22B
Reference Transcript
RefSeq:NM_004892.5 SEC22B
Other Identifiers
11728713_at
11764116_s_at
16669700
209206_PM_at
209206_at
209207_PM_s_at
209207_s_at
231890_PM_at
231890_at
2355618
2355619
2355621
2355622
2355623
2355624
2355625
2355634
2355636
2355637
2355639
2431270
2431272
2431273
2431274
2431275
2431276
41597_s_at
67573_at
68654_at
7904695
87895_s_at
9554
A_23_P200815
A_23_P412392
GE54410
GO:0000139
GO:0005484
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005793
GO:0005794
GO:0006888
GO:0006890
GO:0006914
GO:0012505
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0030133
GO:0030163
GO:0030670
GO:0031201
GO:0031410
GO:0033116
GO:0042470
GO:0043226
GO:0043229
GO:0045732
GO:0048280
GO:0060090
GO:0061024
GO:1902902
HMNXSV003004443
Hs.273830.0.S1_3p_at
Hs.50785.0.A2_3p_at
ILMN_1784238
ILMN_1887230
PH_hs_0023109
TC01001086.hg
g12655032_3p_a_at
Participates
as a member of
ER-to-ERGIC v-SNARES [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
as an output of
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
as an input of
SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)
as a component of
CALR:SEC22B:STX4:TAP:TAPBP [phagocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
SEC22B [phagocytic vesicle membrane]
SEC22B [endoplasmic reticulum membrane]
SEC22B [ER to Golgi transport vesicle membrane]
SEC22B [transport vesicle]
SEC22B [Golgi membrane]
Inferred To
sec22b [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Xenopus tropicalis)
Sec22b [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Mus musculus)
Sec22b [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Rattus norvegicus)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Bos taurus)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Canis familiaris)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Dictyostelium discoideum)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Gallus gallus)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Plasmodium falciparum)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Sus scrofa)
sec22bb [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Danio rerio)
sec22 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Schizosaccharomyces pombe)
SEC22 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Saccharomyces cerevisiae)
Sec22 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Drosophila melanogaster)
sec-22 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_004883.3
OpenTargets
ENSG00000265808
HPA
ENSG00000265808-SEC22B
GeneCards
O75396
Ensembl
ENST00000578049
,
ENSG00000265808
,
ENSP00000463393
PRO
O75396
Pharos - Targets
O75396
PDB
3EGD
,
8HR0
,
2NUT
,
3EGX
,
2NUP
Interactors (75)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P2W9 STX18
1
STX18 [endoplasmic reticulum membrane]
(R-HSA-2029079)
0.773
6
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.725
6
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.675
4
UniProt:O15155 BET1
3
BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688142)
BET1 [transport vesicle]
(R-HSA-6808719)
BET1 [Golgi membrane]
(R-HSA-6807743)
0.671
5
UniProt:Q13190 STX5
5
STX5 [endoplasmic reticulum membrane]
(R-HSA-5689474)
STX5 [ER to Golgi transport vesicle membrane]
(R-HSA-5689838)
STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688157)
STX5 [Golgi membrane]
(R-HSA-6807771)
STX5 [cytosol]
(R-HSA-9613991)
0.669
4
UniProt:O43264 ZW10
1
ZW10 [cytosol]
(R-HSA-377880)
0.643
4
UniProt:Q8WVM8 SCFD1
1
SCFD1 [cytosol]
(R-HSA-5688147)
0.643
5
UniProt:Q12981 BNIP1
1
BNIP1 [endoplasmic reticulum membrane]
(R-HSA-6810950)
0.643
4
UniProt:P43628 KIR2DL3
1
KIR2DL3 [plasma membrane]
(R-HSA-3006532)
0.556
3
UniProt:Q8NC24 RELL2
0.556
3
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:Q86WI0 LHPL1
0.556
3
UniProt:P48165 GJA8
1
GJA8 [endoplasmic reticulum membrane]
(R-HSA-190702)
0.556
3
UniProt:Q8TBP5 F174A
0.556
3
UniProt:Q8IV31 TM139
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:P38484 IFNGR2
1
IFNGR2 [plasma membrane]
(R-HSA-629620)
0.556
3
IntAct:EBI-22589183 CCSB ORF ID
0.556
3
UniProt:Q8N183 NDUFAF2
1
NDUFAF2 [mitochondrial inner membrane]
(R-HSA-5689129)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:Q8TAF8 LHFPL5
1
LHFPL5 [plasma membrane]
(R-HSA-9658860)
0.556
3
UniProt:O95377 GJB5
1
GJB5 [endoplasmic reticulum membrane]
(R-HSA-190643)
0.556
3
UniProt:O95452 GJB6
1
GJB6 [endoplasmic reticulum membrane]
(R-HSA-190633)
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:O14880 MGST3
1
MGST3 [endoplasmic reticulum membrane]
(R-HSA-176053)
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:P31937 HIBADH
1
HIBADH [mitochondrial matrix]
(R-HSA-70882)
0.556
3
UniProt:Q8N5M9 JAGN1
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:Q9P2X0-2 DPM3
0.556
3
UniProt:Q9NVV5-2 AIG1
0.556
3
UniProt:Q96DZ7 T4S19
0.556
3
IntAct:EBI-23642082 CCSB ORF ID
0.556
3
UniProt:Q8TEB9 RHBL4
0.556
3
UniProt:Q99735 MGST2
1
MGST2 [endoplasmic reticulum membrane]
(R-HSA-176058)
0.556
3
UniProt:Q8TBE3 FNDC9
0.556
3
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:P32856-2 STX2
0.556
3
UniProt:Q6ZMG9-2 Q6ZMG92
0.556
3
UniProt:Q9NQQ7-3 Q9NQQ73
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:O95471 CLDN7
2
CLDN7 [cell junction]
(R-HSA-421241)
CLDN7 [plasma membrane]
(R-HSA-420004)
0.556
3
UniProt:P58418 CLRN1
0.556
3
UniProt:O95870 ABHGA
0.556
3
UniProt:Q5T7V8 GORAB
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:Q96MV1 TLCD4
0.556
3
UniProt:Q9NRX6 KISHB
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q8NBD8 T229B
0.556
3
UniProt:Q9Y676 MRPS18B
1
MRPS18B [mitochondrial inner membrane]
(R-HSA-5368234)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q8WU76 SCFD2
0.527
3
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.527
3
UniProt:Q5SQN1 SNP47
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q9UEU0 VTI1B
2
VTI1B [extracellular region]
(R-HSA-8862983)
VTI1B [platelet alpha granule lumen]
(R-HSA-8862964)
0.527
3
UniProt:Q99747 NAPG
1
NAPG [cytosol]
(R-HSA-5688555)
0.527
3
UniProt:A2RU67 F234B
0.527
2
UniProt:Q9UFG5 CS025
0.527
3
UniProt:Q9UNK0 STX8
0.527
4
UniProt:Q2M389 WASC4
0.527
3
UniProt:Q9NZ43 USE1
1
USE1 [endoplasmic reticulum membrane]
(R-HSA-2193119)
0.527
3
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.527
3
UniProt:Q16880 UGT8
1
UGT8 [endoplasmic reticulum membrane]
(R-HSA-9844570)
0.527
3
UniProt:O95249 GOSR1
2
GOSR1 [transport vesicle]
(R-HSA-6784834)
GOSR1 [Golgi membrane]
(R-HSA-6807753)
0.527
3
UniProt:O14653 GOSR2
4
GOSR2 [endoplasmic reticulum membrane]
(R-HSA-5689451)
GOSR2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689800)
GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-535472)
GOSR2 [Golgi membrane]
(R-HSA-6807755)
0.527
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
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