Reactome | AcK-SOD2 [mitochondrial matrix]

AcK-SOD2 [mitochondrial matrix]

Stable Identifier

R-HSA-5688342

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Superoxide dismutase [Mn], mitochondrial ecNumber1.15.1.1/ecNumber, SODM_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
19228881	Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents Kienhöfer, J, Häussler, DJ, Ruckelshausen, F, Muessig, E, Weber, K, Pimentel, D, Ullrich, V, Bürkle, A, Bachschmid, MM	FASEB J.	2009
2462451	Synthesis and processing of the precursor for human mangano-superoxide dismutase Wispé, JR, Clark, JC, Burhans, MS, Kropp, KE, Korfhagen, TR, Whitsett, JA	Biochim. Biophys. Acta	1989

External Reference Information

External Reference

UniProt:P04179 SOD2

Gene Names

SOD2

Chain

transit peptide:1-24, chain:25-222

Reference Genes

BioGPS Gene:6648 SOD2

COSMIC (genes):SOD2 SOD2

CTD Gene:6648 SOD2

dbSNP Gene:6648 SOD2

ENSEMBL:ENSG00000112096 SOD2

ENSEMBL_homo_sapiens_GENE:ENSG00000112096 SOD2

HGNC:11180 SOD2

KEGG Gene (Homo sapiens):6648 SOD2

Monarch:6648 SOD2

NCBI Gene:6648 SOD2

OMIM:147460 SOD2

UCSC:P04179 SOD2

Reference Transcript

Other Identifiers

0000460402

11725024_a_at

11748910_a_at

11758924_x_at

1814

1AP5

1AP6

1EM1

1JA8

1LUV

1LUW

1MSD

1N0J

1N0N

1PL4

1PM9

1QNM

1SZX

1VAR

1XDC

1XIL

1ZSP

1ZTE

1ZUQ

2013

215223_s_at

216841_s_at

221477_s_at

2381906

2982316

2982318

2982320

2982321

2982322

2982323

2982324

2982325

2982326

2982327

2982329

2982331

2982336

2982338

2ADP

2ADQ

2GDS

2P4K

2QKA

2QKC

34666_at

3914704

3C3S

3C3T

4042942

45237_at

58161_at

5GXO

5T30

5VF9

6648

73312_s_at

8130556

A_23_P134176

AAA36622

AAD14248

AAH12423

AAP03428

AAP35613

BAG35908

BAG53464

BAG59382

BAG65521

CAA30687

CAA32502

CAA33228

CAA42066

CAA68533

CAA68791

CAB002013

CCDS34564

CCDS5265

CCDS83143

EAW47630

EAW47631

ENSG00000112096

ENSP00000337127

ENSP00000356021

ENSP00000356022

ENSP00000404804

ENSP00000446252

ENST00000337404

ENST00000367054

ENST00000367055

ENST00000444946

ENST00000538183

EntrezGene:6648

F5GXZ9

F5GYZ5

F5H3C5

F5H4R2

G5E9P6

G8JLJ2

GE80932

GE873297

GO:0000303

GO:0001315

GO:0001836

GO:0003013

GO:0003069

GO:0003674

GO:0004784

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005759

GO:0006357

GO:0006801

GO:0006950

GO:0007005

GO:0007165

GO:0007568

GO:0008150

GO:0008217

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0016491

GO:0019430

GO:0022607

GO:0030145

GO:0030154

GO:0030335

GO:0032364

GO:0034599

GO:0034641

GO:0035722

GO:0040011

GO:0042592

GO:0042802

GO:0043167

GO:0043226

GO:0043524

GO:0046872

GO:0048856

GO:0048870

GO:0050877

GO:0051289

GO:0055114

GO:0065003

GO:0070062

GO:1902176

GO:1904706

GO:1905461

GO:1905932

HGNC:11180

HPA001814

Hs.177781.0.S1_3p_s_at

Hs.318885.1.S1_3p_a_at

Hs.318885.2.S1_3p_a_at

ILMN_1775672

ILMN_1792922

ILMN_2336781

ILMN_2406501

IPR001189

IPR019831

IPR019832

IPR019833

IPR036314

IPR036324

MIM:147460

MIM:612634

NM_000636

NM_001024465

NM_001024466

NM_001322814

NM_001322815

NP_000627

NP_001019636

NP_001019637

NP_001309743

NP_001309744

PF00081

PF02777

PH_hs_0024363

PH_hs_0029952

PR01703

SOD2

SOD2-201

SOD2-202

SOD2-203

SOD2-205

SOD2-210

TC06004141.hg

uc003qsf.6

uc003qsg.5

uc003qsh.5

uc011efu.2

uc011efv.2

UPI000006D275

UPI000020D3E0

UPI00017A8770

X07834_at

X65965_s_at

Participant Of

hasMember

Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2 [mitochondrial matrix]

Other forms of this molecule

SOD2 [mitochondrial matrix]

Inferred To

AcK-SOD2 [mitochondrial matrix] (Arabidopsis thaliana)

AcK-SOD2 [mitochondrial matrix] (Bos taurus)

AcK-SOD2 [mitochondrial matrix] (Caenorhabditis elegans)

AcK-SOD2 [mitochondrial matrix] (Canis familiaris)

AcK-SOD2 [mitochondrial matrix] (Danio rerio)

AcK-SOD2 [mitochondrial matrix] (Dictyostelium discoideum)

AcK-SOD2 [mitochondrial matrix] (Drosophila melanogaster)

AcK-SOD2 [mitochondrial matrix] (Gallus gallus)

AcK-SOD2 [mitochondrial matrix] (Mus musculus)

AcK-SOD2 [mitochondrial matrix] (Oryza sativa)

AcK-SOD2 [mitochondrial matrix] (Plasmodium falciparum)

AcK-SOD2 [mitochondrial matrix] (Rattus norvegicus)

AcK-SOD2 [mitochondrial matrix] (Saccharomyces cerevisiae)

AcK-SOD2 [mitochondrial matrix] (Schizosaccharomyces pombe)

AcK-SOD2 [mitochondrial matrix] (Sus scrofa)

AcK-SOD2 [mitochondrial matrix] (Taeniopygia guttata)

AcK-SOD2 [mitochondrial matrix] (Xenopus tropicalis)

Homologues of AcK-SOD2 [mitochondrial matrix] (Arabidopsis thaliana)

Homologues of AcK-SOD2 [mitochondrial matrix] (Caenorhabditis elegans)

Homologues of AcK-SOD2 [mitochondrial matrix] (Plasmodium falciparum)

Homologues of AcK-SOD2 [mitochondrial matrix] (Sus scrofa)

Modified Residues

Name

N6-acetyl-L-lysine at 122

Coordinate

122

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_001019637.1, NP_001309743.1, NP_001309746.1, NP_000627.2, NP_001309744.1, NP_001019636.1, NP_001309749.1, NP_001309748.1

OpenTargets

ENSG00000285441

GeneCards

P04179

DOCK Blaster

2P4K, 2ADQ, 2ADP, 1LUV, 1LUW, 1PL4, 1JA8, 1ZTE, 1EM1, 1AP5, 1AP6, 1N0J, 1SZX, 1PM9, 3C3S, 1ZSP, 1XIL, 3C3T, 1VAR, 1QNM, 5T30, 1N0N, 1ZUQ, 2QKC, 1XDC, 2GDS, 2QKA, 1MSD, 5VF9

PRO

P04179

BRENDA (Homo sapiens)

1.15.1.1

Orphanet

24936

HMDB Protein

HMDBP01956

PDB

1ZTE, 1XDC, 2ADQ, 1ZUQ, 1PL4, 5VF9, 2QKC, 1JA8, 5T30, 1LUW, 5GXO, 1LUV, 1MSD, 3C3T, 2GDS, 1VAR, 1EM1, 1QNM, 1N0J, 2ADP, 3C3S, 1AP5, 1AP6, 1ZSP, 1PM9, 1SZX, 1N0N, 2QKA, 2P4K, 1XIL

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04179 SOD2	2	SOD2 [mitochondrial matrix] (R-HSA-3299687) AcK-SOD2 [mitochondrial matrix] (R-HSA-5688342)	0.573	2
UniProt:P38340 NTM1			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.488	2