Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AcK-ACSS2 [mitochondrial matrix]
Stable Identifier
R-HSA-5688284
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Acetyl-coenzyme A synthetase, cytoplasmic , Acetate--CoA ligase, Acyl-activating enzyme, Acetyl-CoA synthetase, ACS, AceCS
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Homo sapiens)
Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2 [mitochondrial matrix] (Homo sapiens)
AcK-ACSS2 [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
10843999
Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
Goldstein, JL
,
Luong, A
,
Hannah, VC
J Biol Chem
2000
External Reference Information
External Reference
UniProt:Q9NR19 ACSS2
Gene Names
ACSS2, ACAS2
Chain
chain:1-701
Reference Genes
BioGPS Gene:55902 ACSS2
COSMIC (genes):ACSS2 ACSS2
CTD Gene:55902 ACSS2
dbSNP Gene:55902 ACSS2
ENSEMBL:ENSG00000131069 ACSS2
HGNC:15814 ACSS2
KEGG:hsa:55902 ACSS2
Monarch:55902 ACSS2
NCBI Gene:55902 ACSS2
OMIM:605832 ACSS2
UCSC:Q9NR19 ACSS2
Reference Transcript
RefSeq:NM_018677.3 ACSS2
RefSeq:NM_001076552.2 ACSS2
Other Identifiers
11722346_a_at
11753466_a_at
16912975
234312_PM_s_at
234312_s_at
3883065
3883066
3883067
3883068
3883069
3883077
3883078
3883079
3883080
3883081
3883082
3883083
3883084
3883085
3883086
3883087
3883089
3883090
3883091
3883092
3883093
3883094
3883095
3883096
3883097
3883098
3883099
3883100
3883101
3883102
3883104
3883105
3883106
3883107
3883108
3883109
3883110
3883111
3883112
3883113
55902
57033_at
79418_at
8062041
A_14_P103550
A_24_P156295
GE55390
GE80338
GE84892
GO:0003682
GO:0003713
GO:0003824
GO:0003987
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005759
GO:0005829
GO:0006068
GO:0006085
GO:0006355
GO:0006629
GO:0006790
GO:0007616
GO:0008610
GO:0016208
GO:0016405
GO:0016874
GO:0016878
GO:0019413
GO:0019427
GO:0019542
GO:0043226
GO:0045893
GO:0050218
GO:0050877
GO:0055086
GO:0060090
GO:0140110
GO:0140657
GO:1901135
HMNXSV003014234
Hs.14779.1.A1_3p_a_at
ILMN_1697510
ILMN_1714197
ILMN_1742859
ILMN_2254962
ILMN_2336595
PH_hs_0001395
TC20000245.hg
Participates
as a member of
Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2 [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
ACSS2 [mitochondrial matrix]
ACSS2 [cytosol]
Inferred To
acss2.1 [mitochondrial matrix]
(Xenopus tropicalis)
Acss2 [mitochondrial matrix]
(Rattus norvegicus)
Homologues of AcK-ACSS2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
acs-19 [mitochondrial matrix]
(Caenorhabditis elegans)
AcK-ACSS2 [mitochondrial matrix]
(Dictyostelium discoideum)
AcK-ACSS2 [mitochondrial matrix]
(Gallus gallus)
AcK-ACSS2 [mitochondrial matrix]
(Mus musculus)
AcK-ACSS2 [mitochondrial matrix]
(Plasmodium falciparum)
AcK-ACSS2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
AcK-ACSS2 [mitochondrial matrix]
(Schizosaccharomyces pombe)
AcCoAS [mitochondrial matrix]
(Drosophila melanogaster)
ACSS2 [mitochondrial matrix]
(Bos taurus)
ACSS2 [mitochondrial matrix]
(Canis familiaris)
ACSS2 [mitochondrial matrix]
(Sus scrofa)
Modified Residues
Name
N6-acetyl-L-lysine at 418
Coordinate
418
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
Guide to Pharmacology - Targets
3128
ENSEMBL
ENST00000360596
,
ENSP00000253382
,
ENST00000253382
,
ENSP00000353804
OpenTargets
ENSG00000131069
HPA
ENSG00000131069-ACSS2
PRO
Q9NR19
Pharos - Targets
Q9NR19
GlyGen
Q9NR19
HMDB Protein
HMDBP00037
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text