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SEC22B [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-5688150
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser for interactor UniProt:Q9Y676 MRPS18B
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
SEC22B [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
SEC24A,B:SEC23A bind SEC22B (Homo sapiens)
SEC22B [endoplasmic reticulum membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
Cargo concentration in the ER (Homo sapiens)
SEC24A,B:SEC23A bind SEC22B (Homo sapiens)
SEC22B [endoplasmic reticulum membrane] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)
SEC22B [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75396 SEC22B
Gene Names
SEC22B, SEC22L1
Chain
initiator methionine:, chain:2-215
Reference Genes
BioGPS Gene:9554 SEC22B
COSMIC (genes):SEC22B SEC22B
CTD Gene:9554 SEC22B
dbSNP Gene:9554 SEC22B
ENSEMBL:ENSG00000265808 SEC22B
ENSEMBL_homo_sapiens_GENE:ENSG00000265808.4 SEC22B
HGNC:10700 SEC22B
KEGG Gene (Homo sapiens):9554 SEC22B
Monarch:9554 SEC22B
NCBI Gene:9554 SEC22B
OMIM:604029 SEC22B
UCSC:O75396 SEC22B
Reference Transcript
RefSeq:NM_004892.5 SEC22B
Other Identifiers
11728713_at
11764116_s_at
16669700
209206_PM_at
209206_at
209207_PM_s_at
209207_s_at
231890_PM_at
231890_at
2355618
2355619
2355621
2355622
2355623
2355624
2355625
2355634
2355636
2355637
2355639
2431270
2431272
2431273
2431274
2431275
2431276
41597_s_at
67573_at
68654_at
7904695
87895_s_at
9554
A_23_P200815
A_23_P412392
GE54410
GO:0000139
GO:0005484
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0005793
GO:0005794
GO:0006888
GO:0006890
GO:0006914
GO:0012505
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0030133
GO:0030163
GO:0030670
GO:0031201
GO:0031410
GO:0033116
GO:0042470
GO:0043226
GO:0043229
GO:0045732
GO:0048280
GO:0060090
GO:0061024
GO:1902902
HMNXSV003004443
Hs.273830.0.S1_3p_at
Hs.50785.0.A2_3p_at
ILMN_1784238
ILMN_1887230
PH_hs_0023109
TC01001086.hg
g12655032_3p_a_at
Participates
as an output of
NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)
as a component of
SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC22B:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)
SEC24A,B:SEC23A:SEC22B [endoplasmic reticulum membrane] (Homo sapiens)
as an input of
SEC24A,B:SEC23A bind SEC22B (Homo sapiens)
Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)
as a member of
ER-to-ERGIC v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
SEC22B [phagocytic vesicle membrane]
SEC22B [ER to Golgi transport vesicle membrane]
SEC22B [transport vesicle]
SEC22B [Golgi membrane]
Inferred To
Sec22b [endoplasmic reticulum membrane]
(Mus musculus)
Sec22b [endoplasmic reticulum membrane]
(Rattus norvegicus)
sec22b [endoplasmic reticulum membrane]
(Xenopus tropicalis)
SEC22B [endoplasmic reticulum membrane]
(Bos taurus)
SEC22B [endoplasmic reticulum membrane]
(Canis familiaris)
SEC22B [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
SEC22B [endoplasmic reticulum membrane]
(Gallus gallus)
SEC22B [endoplasmic reticulum membrane]
(Plasmodium falciparum)
SEC22B [endoplasmic reticulum membrane]
(Sus scrofa)
sec-22 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
sec22 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
Sec22 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
SEC22 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
sec22bb [endoplasmic reticulum membrane]
(Danio rerio)
Cross References
RefSeq
NP_004883.3
OpenTargets
ENSG00000265808
HPA
ENSG00000265808-SEC22B
GeneCards
O75396
Ensembl
ENST00000578049
,
ENSG00000265808
,
ENSP00000463393
PRO
O75396
Pharos - Targets
O75396
PDB
3EGD
,
8HR0
,
2NUT
,
3EGX
,
2NUP
Interactors (75)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P2W9 STX18
1
STX18 [endoplasmic reticulum membrane]
(R-HSA-2029079)
0.773
6
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.725
6
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.675
4
UniProt:O15155 BET1
3
BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688142)
BET1 [transport vesicle]
(R-HSA-6808719)
BET1 [Golgi membrane]
(R-HSA-6807743)
0.671
5
UniProt:Q13190 STX5
5
STX5 [endoplasmic reticulum membrane]
(R-HSA-5689474)
STX5 [ER to Golgi transport vesicle membrane]
(R-HSA-5689838)
STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688157)
STX5 [Golgi membrane]
(R-HSA-6807771)
STX5 [cytosol]
(R-HSA-9613991)
0.669
4
UniProt:O43264 ZW10
1
ZW10 [cytosol]
(R-HSA-377880)
0.643
4
UniProt:Q8WVM8 SCFD1
1
SCFD1 [cytosol]
(R-HSA-5688147)
0.643
5
UniProt:Q12981 BNIP1
1
BNIP1 [endoplasmic reticulum membrane]
(R-HSA-6810950)
0.643
4
UniProt:P43628 KIR2DL3
1
KIR2DL3 [plasma membrane]
(R-HSA-3006532)
0.556
3
UniProt:Q8NC24 RELL2
0.556
3
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:Q86WI0 LHPL1
0.556
3
UniProt:P48165 GJA8
1
GJA8 [endoplasmic reticulum membrane]
(R-HSA-190702)
0.556
3
UniProt:Q8TBP5 F174A
0.556
3
UniProt:Q8IV31 TM139
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:P38484 IFNGR2
1
IFNGR2 [plasma membrane]
(R-HSA-629620)
0.556
3
IntAct:EBI-22589183 CCSB ORF ID
0.556
3
UniProt:Q8N183 NDUFAF2
1
NDUFAF2 [mitochondrial inner membrane]
(R-HSA-5689129)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:Q8TAF8 LHFPL5
1
LHFPL5 [plasma membrane]
(R-HSA-9658860)
0.556
3
UniProt:O95377 GJB5
1
GJB5 [endoplasmic reticulum membrane]
(R-HSA-190643)
0.556
3
UniProt:O95452 GJB6
1
GJB6 [endoplasmic reticulum membrane]
(R-HSA-190633)
0.556
3
UniProt:Q9H6H4 REEP4
0.556
3
UniProt:O14880 MGST3
1
MGST3 [endoplasmic reticulum membrane]
(R-HSA-176053)
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:P31937 HIBADH
1
HIBADH [mitochondrial matrix]
(R-HSA-70882)
0.556
3
UniProt:Q8N5M9 JAGN1
0.556
3
UniProt:Q9GZR5 ELOVL4
1
ELOVL4 [endoplasmic reticulum membrane]
(R-HSA-548705)
0.556
3
UniProt:Q9P2X0-2 DPM3
0.556
3
UniProt:Q9NVV5-2 AIG1
0.556
3
UniProt:Q96DZ7 T4S19
0.556
3
IntAct:EBI-23642082 CCSB ORF ID
0.556
3
UniProt:Q8TEB9 RHBL4
0.556
3
UniProt:Q99735 MGST2
1
MGST2 [endoplasmic reticulum membrane]
(R-HSA-176058)
0.556
3
UniProt:Q8TBE3 FNDC9
0.556
3
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:P32856-2 STX2
0.556
3
UniProt:Q6ZMG9-2 Q6ZMG92
0.556
3
UniProt:Q9NQQ7-3 Q9NQQ73
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:O95471 CLDN7
2
CLDN7 [cell junction]
(R-HSA-421241)
CLDN7 [plasma membrane]
(R-HSA-420004)
0.556
3
UniProt:P58418 CLRN1
0.556
3
UniProt:O95870 ABHGA
0.556
3
UniProt:Q5T7V8 GORAB
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:Q96MV1 TLCD4
0.556
3
UniProt:Q9NRX6 KISHB
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q8NBD8 T229B
0.556
3
UniProt:Q9Y676 MRPS18B
1
MRPS18B [mitochondrial inner membrane]
(R-HSA-5368234)
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q8WU76 SCFD2
0.527
3
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.527
3
UniProt:Q5SQN1 SNP47
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q9UEU0 VTI1B
2
VTI1B [extracellular region]
(R-HSA-8862983)
VTI1B [platelet alpha granule lumen]
(R-HSA-8862964)
0.527
3
UniProt:Q99747 NAPG
1
NAPG [cytosol]
(R-HSA-5688555)
0.527
3
UniProt:A2RU67 F234B
0.527
2
UniProt:Q9UFG5 CS025
0.527
3
UniProt:Q9UNK0 STX8
0.527
4
UniProt:Q2M389 WASC4
0.527
3
UniProt:Q9NZ43 USE1
1
USE1 [endoplasmic reticulum membrane]
(R-HSA-2193119)
0.527
3
UniProt:O43752 STX6
2
STX6 [trans-Golgi network membrane]
(R-HSA-6811007)
STX6 [Golgi membrane]
(R-HSA-6811004)
0.527
3
UniProt:Q16880 UGT8
1
UGT8 [endoplasmic reticulum membrane]
(R-HSA-9844570)
0.527
3
UniProt:O95249 GOSR1
2
GOSR1 [transport vesicle]
(R-HSA-6784834)
GOSR1 [Golgi membrane]
(R-HSA-6807753)
0.527
3
UniProt:O14653 GOSR2
4
GOSR2 [endoplasmic reticulum membrane]
(R-HSA-5689451)
GOSR2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689800)
GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-535472)
GOSR2 [Golgi membrane]
(R-HSA-6807755)
0.527
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
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