MRN complex binds RBBP8

Stable Identifier
R-HSA-5687465
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MRN complex binds RBBP8
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In G1 phase, RBBP8 (CtIP) homotetramer associates with the MRN complex (MRE11A:RAD50:NBN) at DNA double strand breaks (DSBs) but does not undergo CDK2-mediated phosphorylation and is therefore unable to recruit BRCA1 (Yun et al. 2009). The activation of ATM DNA damage checkpoint is not needed for microhomology-mediated end joining (MMEJ or alt-NHEJ) (Rahal et al. 2010). MMEJ can also be triggered at other stages of the cell cycle, besides G1, when the amount of DNA DSBs overwhelms high fidelity DNA repair machinery (Liang et al. 2005).

Literature References
PubMed ID Title Journal Year
20647759 ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

Rahal, EA, Henricksen, LA, Li, Y, Williams, RS, Tainer, JA, Dixon, K

Cell Cycle 2010
16012167 Modulation of DNA end joining by nuclear proteins

Liang, L, Deng, L, Chen, Y, Li, GC, Shao, C, Tischfield, JA

J. Biol. Chem. 2005
19357644 CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, MH, Hiom, K

Nature 2009
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
MRN complex binds RBBP8 (Bos taurus)
MRN complex binds RBBP8 (Canis familiaris)
MRN complex binds RBBP8 (Danio rerio)
MRN complex binds RBBP8 (Mus musculus)
MRN complex binds RBBP8 (Rattus norvegicus)
MRN complex binds RBBP8 (Schizosaccharomyces pombe)
MRN complex binds RBBP8 (Sus scrofa)
MRN complex binds RBBP8 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-04-07)