MRN complex binds RBBP8

Stable Identifier
R-HSA-5687465
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In G1 phase, RBBP8 (CtIP) homotetramer associates with the MRN complex (MRE11A:RAD50:NBN) at DNA double strand breaks (DSBs) but does not undergo CDK2-mediated phosphorylation and is therefore unable to recruit BRCA1 (Yun et al. 2009). The activation of ATM DNA damage checkpoint is not needed for microhomology-mediated end joining (MMEJ or alt-NHEJ) (Rahal et al. 2010). MMEJ can also be triggered at other stages of the cell cycle, besides G1, when the amount of DNA DSBs overwhelms high fidelity DNA repair machinery (Liang et al. 2005).

Literature References
PubMed ID Title Journal Year
20647759 ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

Rahal, EA, Henricksen, LA, Li, Y, Williams, RS, Tainer, JA, Dixon, K

Cell Cycle 2010
16012167 Modulation of DNA end joining by nuclear proteins

Liang, L, Deng, L, Chen, Y, Li, GC, Shao, C, Tischfield, JA

J. Biol. Chem. 2005
19357644 CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, MH, Hiom, K

Nature 2009
Participants
Participant Of
Orthologous Events
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Created