The complex of MRN (MRE11A:RAD50:NBN) and RBBP8 (CtIP) performs a limited resection of DNA double strand breaks (DSBs) in the process of microhomology-mediated end joining (MMEJ) (Yun et al. 2009). ATM activation inhibits MMEJ-related resection of DNA DSBs by MRN, possibly through MRN phosphorylation (Rahal et al. 2010).
Tainer, JA, Henricksen, LA, Dixon, K, Williams, RS, Rahal, EA, Li, Y
Yun, MH, Hiom, K
endodeoxyribonuclease activity of DNA DSB:MRN:RBBP8 [nucleoplasm]
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