MRN and RBBP8 resect DNA DSBs in MMEJ

Stable Identifier
R-HSA-5687464
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The complex of MRN (MRE11A:RAD50:NBN) and RBBP8 (CtIP) performs a limited resection of DNA double strand breaks (DSBs) in the process of microhomology-mediated end joining (MMEJ) (Yun et al. 2009). ATM activation inhibits MMEJ-related resection of DNA DSBs by MRN, possibly through MRN phosphorylation (Rahal et al. 2010).

Literature References
PubMed ID Title Journal Year
19357644 CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, MH, Hiom, K

Nature 2009
20647759 ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

Rahal, EA, Henricksen, LA, Li, Y, Williams, RS, Tainer, JA, Dixon, K

Cell Cycle 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endodeoxyribonuclease activity of DNA DSB:MRN:RBBP8 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created