Deleted in malignant brain tumors 1 protein (DMBT1 aka Gp-340, Hensin, salivary agglutinin) is a binding protein that could play a role in mucosal innate immunity. It is secreted into the broncho-alveolar surface lining fluid and in saliva. DMTB1 can bind surfactant proteins SFTPA and D in macrophage tissues, the resulting complex being able to interact with and agglutinate several Gram-negative and Gram-positive bacteria (Holmskov et al. 1999, Ligtenberg et al. 2001; reviews - Lightenberg et al. 2007, Madsen et al. 2010). DMBT1 has been proposed as a tumor suppressor gene candidate in human brain tumors. Two mutations, one of which resulted in an amino acid change (Q420H), occurred in glioblastomas (Mueller et al. 2002).
Mollenhauer, J, Madsen, J, Holmskov, U
Madsen, J, Poustka, A, Kliem, A, Reid, KB, Mollenhauer, J, Holmskov, U, Skjodt, K, Tornoe, I, Vitved, L, Gronlund, J
Groenink, J, Ligtenberg, TJ, Holmskov, U, Bikker, FJ, Nieuw Amerongen, AV, Leth-Larsen, R, Veerman, EC, Tornoe, I
Mollenhauer, J, Ligtenberg, AJ, Nieuw Amerongen, AV, Veerman, EC
Mollenhauer, J, Stockhammer, F, Poustka, A, von Deimling, A, Mueller, W
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