Reactome | DMBT1 binds SFTPD 12mer, SFTPAs

DMBT1 binds SFTPD 12mer, SFTPAs

Stable Identifier

R-HSA-5687284

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Deleted in malignant brain tumors 1 protein (DMBT1 aka Gp-340, Hensin, salivary agglutinin) is a binding protein that could play a role in mucosal innate immunity. It is secreted into the broncho-alveolar surface lining fluid and in saliva. DMTB1 can bind surfactant proteins SFTPA and D in macrophage tissues, the resulting complex being able to interact with and agglutinate several Gram-negative and Gram-positive bacteria (Holmskov et al. 1999, Ligtenberg et al. 2001; reviews - Lightenberg et al. 2007, Madsen et al. 2010). DMBT1 has been proposed as a tumor suppressor gene candidate in human brain tumors. Two mutations, one of which resulted in an amino acid change (Q420H), occurred in glioblastomas (Mueller et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
20418254	Review: Gp-340/DMBT1 in mucosal innate immunity Mollenhauer, J, Madsen, J, Holmskov, U	Innate Immun	2010
10485905	Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D Madsen, J, Poustka, A, Kliem, A, Reid, KB, Mollenhauer, J, Holmskov, U, Skjodt, K, Tornoe, I, Vitved, L, Gronlund, J	Proc. Natl. Acad. Sci. U.S.A.	1999
11563989	Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340 Groenink, J, Ligtenberg, TJ, Holmskov, U, Bikker, FJ, Nieuw Amerongen, AV, Leth-Larsen, R, Veerman, EC, Tornoe, I	Biochem. J.	2001
18020944	Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer Mollenhauer, J, Ligtenberg, AJ, Nieuw Amerongen, AV, Veerman, EC	Biol. Chem.	2007
12185598	Rare mutations of the DMBT1 gene in human astrocytic gliomas Mollenhauer, J, Stockhammer, F, Poustka, A, von Deimling, A, Mueller, W	Oncogene	2002