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TDP2 [nucleoplasm]
Stable Identifier
R-HSA-5687253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Tyrosyl-DNA phosphodiesterase 2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
E2F6:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
(TDP1,TDP2) [nucleoplasm] (Homo sapiens)
TDP2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Nonhomologous End-Joining (NHEJ) (Homo sapiens)
TDP1 and TDP2 process unligatable DSB ends (Homo sapiens)
(TDP1,TDP2) [nucleoplasm] (Homo sapiens)
TDP2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
E2F6:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
(TDP1,TDP2) [nucleoplasm] (Homo sapiens)
TDP2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95551 TDP2
Gene Names
TDP2, EAP2, TTRAP, AD-022
Chain
chain:1-362
Reference Genes
BioGPS Gene:51567 TDP2
COSMIC (genes):TDP2 TDP2
CTD Gene:51567 TDP2
dbSNP Gene:51567 TDP2
ENSEMBL:ENSG00000111802.14 TDP2
HGNC:17768 TDP2
KEGG Gene (Homo sapiens):51567 TDP2
Monarch:51567 TDP2
NCBI Gene:51567 TDP2
OMIM:605764 TDP2
UCSC:O95551 TDP2
Reference Transcript
RefSeq:NM_016614.2 TDP2
Other Identifiers
11717404_x_at
11747640_a_at
17016190
202266_PM_at
202266_at
2945646
2945647
2945648
2945649
2945650
2945651
2945653
2945654
2945655
2945667
2945670
2945671
34825_at
51567
8124262
A_23_P8311
GE82149
GO:0000287
GO:0003677
GO:0003697
GO:0003714
GO:0003824
GO:0004518
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006281
GO:0006302
GO:0006351
GO:0006355
GO:0006974
GO:0007166
GO:0016235
GO:0016604
GO:0016605
GO:0016787
GO:0023052
GO:0030145
GO:0030154
GO:0036317
GO:0043226
GO:0045892
GO:0046872
GO:0048666
GO:0048856
GO:0070260
GO:0090305
GO:0140097
GO:0140098
GO:0140110
HMNXSV003042217
ILMN_1785821
ILMN_2183216
PH_hs_0023066
TC06001327.hg
g7705261_3p_at
Participates
as a candidate of
(TDP1,TDP2) [nucleoplasm] (Homo sapiens)
Inferred To
TDP2 [nucleoplasm]
(Bos taurus)
TDP2 [nucleoplasm]
(Canis familiaris)
TDP2 [nucleoplasm]
(Danio rerio)
TDP2 [nucleoplasm]
(Dictyostelium discoideum)
TDP2 [nucleoplasm]
(Gallus gallus)
TDP2 [nucleoplasm]
(Mus musculus)
TDP2 [nucleoplasm]
(Rattus norvegicus)
TDP2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_057698.2
OpenTargets
ENSG00000111802
ZINC - Substances
TYDP2_HUMAN
ZINC - Biogenic
TYDP2_HUMAN
ZINC target
O95551
PRO
O95551
PDB
5J3P
,
5INO
,
6Q01
,
5J3S
,
6Q00
ZINC - Investigational
TYDP2_HUMAN
GeneCards
O95551
HPA
ENSG00000111802-TDP2
Ensembl
ENSP00000367440
,
ENSG00000111802
,
ENST00000378198
Pharos - Targets
O95551
ZINC - Predictions - Purchasable
TYDP2_HUMAN
Orphanet
22973
HMDB Protein
HMDBP14491
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.488
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.488
2
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