MYC positively regulates MAPKAPK5 gene expression

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Reaction [omitted]
Homo sapiens
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MYC binds to consensus sites in the MAPKAPK5 promoter to promote transcription. This completes a negative feedback loop controlling MYC expression, as MAPKAPK5 itself negatively regulates MYC protein levels through FOXO3 and miR-34B and C (Kress et al, 2011). This pathway is disrupted in colorectal cancer, leading to aberrant cellular proliferation (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).

Literature References
PubMed ID Title Journal Year
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Dumitriu, G, Kostenko, S, Moens, U

J Mol Signal 2012
21329882 The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

Kress, TR, Eilers, M, Roepman, P, Bushell, M, Samans, B, Cannell, IG, Rosenwald, A, Gaestel, M, Burgering, BM, Brenkman, AB

Mol. Cell 2011
21329875 More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer

Myant, K, Sansom, OJ

Mol. Cell 2011
This event is regulated
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