IGF2BP1 represses translation of MAPK4 mRNA

Stable Identifier
R-HSA-5687105
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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IGF2BP1 represses translation of MAPK4 mRNA
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Binding of IGF2BP1 to the 3' UTR of MAPK4 mRNA inhibits its translation and in this way antagonizes the MAPKAPK5-dependent phosphorylation of HSBP1 (Stohr et al, 2012; Kostenko et al, 2009a; reviewed in Kostenko et al, 2012).

Literature References
PubMed ID Title Journal Year
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Dumitriu, G, Kostenko, S, Moens, U

J Mol Signal 2012
19166925 PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5

Kostenko, S, Moens, U, Johannessen, M

Cell. Signal. 2009
22279049 IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling

Glass, M, Stöhr, N, Lederer, M, Singer, RH, Hüttelmaier, S, Reinke, C, Köhn, M

Genes Dev. 2012
Participants
Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
IGF2BP1:MAPK4 mRNA [cytosol] (Homo sapiens)
Authored
Rothfels, K  (2015-03-30)
Reviewed
Moens, U  (2015-04-24)
Soulez, M  (2015-05-12)
Mathien, S  (2015-05-12)
Seternes, OM  (2015-05-05)
Meloche, S  (2015-05-12)
Created
Rothfels, K  (2015-04-06)
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