p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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MAPK6-dependent phosphorylation of NCOA3 S857 promotes its interaction with the transcription factor ETV4 and increases the occupancy at promoters of the MMP2 and 10 genes in vivo as assessed by ChIP (Long et al, 2012; Qin et al, 2008; Yan et al, 2008). MMP gene expression is associated with invasiveness in lung and breast cancer, and MAPK6 is highly expressed in a subset of human lung carcinomas (Long et al, 2012; Qin et al, 2008; Yan et al, 2008; Li et al, 2008; reviewed in Kostenko et al, 2012).
Literature References
PubMed ID Title Journal Year
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Dumitriu, G, Kostenko, S, Moens, U

J Mol Signal 2012
18593949 Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

Erdem, H, Tsai, SY, Yan, J, Li, R, Tsai, MJ, Ittmann, M, Ayala, G, Cai, Y, Yu-Lee, LY

Cancer Res. 2008
22505454 ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

O'Malley, BW, Foulds, CE, Tsai, SY, Liu, J, Long, W, Tsai, MJ, Wistuba, II, Lonard, DM, Ding, C, Qin, J, Qin, J, Solis, LM

J. Clin. Invest. 2012
18644862 The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression

O'Malley, BW, Redmond, A, Yuan, Y, Chen, H, Qin, L, Xu, J, Young, L, Liao, L

Mol. Cell. Biol. 2008
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