IGF2BP1 is a cytosolic RNA-binding protein that recruits target transcripts to RNP particles for storage or transport. These RNP particles also restrict access of the translational machinery and micro-RNAs to the transcript and in this way affect rates of protein translation (reviewed in Bell et al, 2013). IGFBP1 binds to the 3' UTR of MAPK4 mRNA and inhibits its translation. This antagonizes MAPKAPK5 activation and HSBP1 phosphorylation and in this manner affects F-actin rearrangements and cell motility (Stohr et al, 2012; Kostenko et al, 2009a; reviewed in Kostenko et al, 2012).
Dumitriu, G, Kostenko, S, Moens, U
Bell, JL, Pazaitis, N, Mühleck, B, Wächter, K, Lederer, M, Hüttelmaier, S, Köhn, M
Kostenko, S, Moens, U, Johannessen, M
Glass, M, Stöhr, N, Lederer, M, Singer, RH, Hüttelmaier, S, Reinke, C, Köhn, M
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