IGF2BP1 binds MAPK4 mRNA

Stable Identifier
Reaction [binding]
Homo sapiens
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IGF2BP1 is a cytosolic RNA-binding protein that recruits target transcripts to RNP particles for storage or transport. These RNP particles also restrict access of the translational machinery and micro-RNAs to the transcript and in this way affect rates of protein translation (reviewed in Bell et al, 2013). IGFBP1 binds to the 3' UTR of MAPK4 mRNA and inhibits its translation. This antagonizes MAPKAPK5 activation and HSBP1 phosphorylation and in this manner affects F-actin rearrangements and cell motility (Stohr et al, 2012; Kostenko et al, 2009a; reviewed in Kostenko et al, 2012).
Literature References
PubMed ID Title Journal Year
22800433 Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Dumitriu, G, Kostenko, S, Moens, U

J Mol Signal 2012
23069990 Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

Bell, JL, Pazaitis, N, Mühleck, B, Wächter, K, Lederer, M, Hüttelmaier, S, Köhn, M

Cell. Mol. Life Sci. 2013
19166925 PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5

Kostenko, S, Moens, U, Johannessen, M

Cell. Signal. 2009
22279049 IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling

Glass, M, Stöhr, N, Lederer, M, Singer, RH, Hüttelmaier, S, Reinke, C, Köhn, M

Genes Dev. 2012
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