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Go!
ub-MAPK6 [cytosol]
Stable Identifier
R-HSA-5687000
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ERK3, PRKM6
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9Y4C2 TCAF1
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
MAPK6 is degraded by the 26S proteasome (Homo sapiens)
ub-MAPK6 [cytosol] (Homo sapiens)
MAPK6 is ubiquitinated at the N-terminal (Homo sapiens)
ub-MAPK6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16659 MAPK6 gene
Gene Names
MAPK6 gene, MAPK6, ERK3, PRKM6
Chain
chain:1-721
Reference Genes
BioGPS Gene:5597 MAPK6 gene
CTD Gene:5597 MAPK6 gene
dbSNP Gene:5597 MAPK6 gene
ENSEMBL:ENSG00000069956 MAPK6 gene
ENSEMBL_homo_sapiens_GENE:ENSG00000069956.14 MAPK6 gene
HGNC:6879 MAPK6 gene
KEGG Gene (Homo sapiens):5597 MAPK6 gene
Monarch:5597 MAPK6 gene
NCBI Gene:5597 MAPK6 gene
OMIM:602904 MAPK6 gene
UCSC:Q16659 MAPK6 gene
Reference Transcript
RefSeq:XM_011521782.1 MAPK6 gene
RefSeq:XM_005254539.3 MAPK6 gene
RefSeq:NM_002748.3 MAPK6 gene
RefSeq:XM_005254538.2 MAPK6 gene
RefSeq:XM_005254537.2 MAPK6 gene
Other Identifiers
11722796_a_at
16801179
207121_PM_s_at
207121_s_at
243831_PM_at
243831_at
3098308
3111632
3111634
3133821
3246221
3246228
3511512
3511517
3594130
3594142
3594143
3594144
3594145
3594146
3594147
3594150
3594153
3594154
3594155
3594156
3594157
3594158
3594160
36926_at
3926771
5597
76525_at
7983763
A_14_P137682
A_23_P3204
A_24_P333663
GE728188
GE79439
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0006468
GO:0007049
GO:0007165
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0023052
GO:0030154
GO:0032156
GO:0032991
GO:0035556
GO:0036211
GO:0043226
GO:0046982
GO:0048856
GO:0060999
GO:0106310
GO:0140096
HMNXSV003053235
Hs.122812.0.A1_3p_at
ILMN_1757287
PH_hs_0029556
TC15000417.hg
X80692_at
g4506090_3p_a_at
Participates
as an output of
MAPK6 is ubiquitinated at the N-terminal (Homo sapiens)
as an input of
MAPK6 is degraded by the 26S proteasome (Homo sapiens)
Other forms of this molecule
MAPK6 [cytosol]
p-S189 MAPK6 [cytosol]
p-S189 MAPK6 [nucleoplasm]
MAPK6 [nucleoplasm]
p-3S,T MAPK6 [nucleoplasm]
Inferred To
Homologues of ub-MAPK6 [cytosol]
(Saccharomyces cerevisiae)
Homologues of ub-MAPK6 [cytosol]
(Schizosaccharomyces pombe)
ub-MAPK6 [cytosol]
(Bos taurus)
ub-MAPK6 [cytosol]
(Caenorhabditis elegans)
ub-MAPK6 [cytosol]
(Canis familiaris)
ub-MAPK6 [cytosol]
(Danio rerio)
ub-MAPK6 [cytosol]
(Dictyostelium discoideum)
ub-MAPK6 [cytosol]
(Gallus gallus)
ub-MAPK6 [cytosol]
(Mus musculus)
ub-MAPK6 [cytosol]
(Plasmodium falciparum)
ub-MAPK6 [cytosol]
(Rattus norvegicus)
ub-MAPK6 [cytosol]
(Saccharomyces cerevisiae)
ub-MAPK6 [cytosol]
(Schizosaccharomyces pombe)
ub-MAPK6 [cytosol]
(Sus scrofa)
ub-MAPK6 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
modified L-methionine residue (K48polyUb [cytosol]) at 1
Coordinate
1
Modification
K48polyUb [cytosol]
PsiMod Name
modified L-methionine residue
PsiMod Definition
A protein modification that modifies an L-methionine residue.
Cross References
RefSeq
XP_005254596.1
,
XP_005254594.1
,
NP_002739.1
,
XP_005254595.1
,
XP_011520084.1
ZINC - World Drugs
MK06_HUMAN
Guide to Pharmacology - Targets
2092
ZINC - FDA approved
MK06_HUMAN
ZINC - Substances
MK06_HUMAN
ZINC - Biogenic
MK06_HUMAN
ZINC target
Q16659
PRO
Q16659
PDB
6YLC
,
6YKY
,
6YLL
,
7AQB
ZINC - Investigational
MK06_HUMAN
HPA
ENSG00000069956-MAPK6
GeneCards
Q16659
Ensembl
ENST00000680777
,
ENST00000680652
,
ENSP00000506184
,
ENSP00000505601
,
ENST00000681888
,
ENSP00000509662
,
ENSP00000261845
,
ENSP00000505862
,
ENST00000691380
,
ENSP00000506036
,
ENST00000261845
,
ENST00000680066
,
ENSG00000069956
Pharos - Targets
Q16659
ZINC - Predictions - Purchasable
MK06_HUMAN
HMDB Protein
HMDBP01527
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IW41 MAPKAPK5
5
p-T182 MAPKAPK5 [cytosol]
(R-HSA-5687004)
p-S115 MAPKAPK5 [cytosol]
(R-HSA-5687028)
p-S115 MAPKAPK5 [nucleoplasm]
(R-HSA-5687026)
MAPKAPK5 [nucleoplasm]
(R-HSA-2562517)
p-T182-MAPKAPK5 [nucleoplasm]
(R-HSA-3239018)
0.917
12
UniProt:O95714 HERC2
5
HERC2 [nucleoplasm]
(R-HSA-4551680)
p-T4827-HERC2 [nucleoplasm]
(R-HSA-5682601)
p-T4827,SUMO1-HERC2 [nucleoplasm]
(R-HSA-5682615)
HERC2 [cytosol]
(R-HSA-975975)
monoSUMO1-HERC2 [nucleoplasm]
(R-HSA-4551758)
0.837
8
UniProt:Q8IW41-2 MAPKAPK5
0.742
6
UniProt:Q96JN8 NEUL4
0.725
5
UniProt:Q9H6Z9 EGLN3
2
EGLN3 [nucleoplasm]
(R-HSA-1234104)
EGLN3 [cytosol]
(R-HSA-1234115)
0.681
6
UniProt:P02647 APOA1
11
APOA1(25-266) [secretory granule lumen]
(R-HSA-350761)
APOA1(25-267) [cytosol]
(R-HSA-2395781)
APOA1(25-267) [early endosome]
(R-HSA-2429641)
APOA1(25-267) [endoplasmic reticulum lumen]
(R-HSA-174640)
APOA1(19-266) [extracellular region]
(R-HSA-264771)
APOA1(25-266) [plasma membrane]
(R-HSA-216742)
Variant apolipoprotein AI [extracellular region]
(R-HSA-976865)
APOA1(25-266) [endocytic vesicle lumen]
(R-HSA-2239460)
p-APOA1 [endoplasmic reticulum lumen]
(R-HSA-8957081)
APOA1 [endoplasmic reticulum lumen]
(R-HSA-8956724)
APOA1(25-266) [extracellular region]
(R-HSA-174720)
0.659
3
UniProt:Q9Y4C2 TCAF1
0.643
4
UniProt:Q13011 ECH1
3
ECH1 [mitochondrial matrix]
(R-HSA-9838037)
ECH1(1-328) [peroxisomal matrix]
(R-HSA-9033140)
ECH1(1-328) [cytosol]
(R-HSA-9033152)
0.643
3
UniProt:Q9GZV1 ANKR2
0.556
7
UniProt:Q99613 EIF3C
1
EIF3C [cytosol]
(R-HSA-72550)
0.547
2
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.547
2
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.547
2
UniProt:Q96GD4 AURKB
3
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [nucleoplasm]
(R-HSA-4655360)
AURKB [cytosol]
(R-HSA-174231)
0.527
2
UniProt:Q6P1M0 SLC27A4
6
SLC27A4 A92T [plasma membrane]
(R-HSA-5627896)
SLC27A4 R583H [plasma membrane]
(R-HSA-5627897)
SLC27A4 Q300R [plasma membrane]
(R-HSA-5627918)
SLC27A4 S247P [plasma membrane]
(R-HSA-5627907)
SLC27A4 C168* [plasma membrane]
(R-HSA-5627910)
SLC27A4 [plasma membrane]
(R-HSA-879638)
0.527
2
UniProt:P02675 FGB
5
FGB(31-491) [platelet alpha granule lumen]
(R-HSA-140921)
FGB(31-491) [extracellular region]
(R-HSA-140846)
FGB [plasma membrane]
(R-HSA-140917)
FGB(31-44) [extracellular region]
(R-HSA-140876)
FGB [extracellular region]
(R-HSA-140584)
0.527
2
UniProt:Q14147 DHX34
0.527
2
UniProt:P00738 HP
7
HP [specific granule lumen]
(R-HSA-6799622)
HP [extracellular region]
(R-HSA-6799677)
HP [tertiary granule lumen]
(R-HSA-6800879)
5xHC-HP(162-406) [endocytic vesicle lumen]
(R-HSA-2230973)
7xHC-HP(19-160) [endocytic vesicle lumen]
(R-HSA-2230994)
5xHC-HP(162-406) [extracellular region]
(R-HSA-2168875)
7xHC-HP(19-160) [extracellular region]
(R-HSA-2168848)
0.527
2
UniProt:Q8IZT6 ASPM
0.527
2
UniProt:P69905 HBA1
4
CO-H+-HBA1 [cytosol]
(R-HSA-1237026)
HBA1 [cytosol]
(R-HSA-1008268)
HBA1 [endocytic vesicle lumen]
(R-HSA-2230966)
HBA1 [extracellular region]
(R-HSA-2168862)
0.527
2
UniProt:Q96JN8-2 NEURL4
0.527
5
UniProt:O75521 ECI2
0.527
2
UniProt:P68871 HBB
8
CO-H+-HBB [cytosol]
(R-HSA-1237013)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
HBB [extracellular region]
(R-HSA-2168872)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [cytosol]
(R-HSA-1008196)
HBB [lysosomal lumen]
(R-HSA-9625193)
0.527
2
UniProt:Q5SW79 CE170
0.527
2
UniProt:P02787 TF
6
apoTF [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869140)
TF [secretory granule lumen]
(R-HSA-350704)
apoTF [extracellular region]
(R-HSA-350754)
apoTF [endosome membrane]
(R-HSA-917974)
p-TF [endoplasmic reticulum lumen]
(R-HSA-8957001)
TF [endoplasmic reticulum lumen]
(R-HSA-8956763)
0.527
2
UniProt:P02765 AHSG
5
AHSG [platelet alpha granule lumen]
(R-HSA-8848910)
AHSG [extracellular region]
(R-HSA-6804820)
AHSG [secretory granule lumen]
(R-HSA-6804806)
p-AHSG [endoplasmic reticulum lumen]
(R-HSA-8957019)
AHSG [endoplasmic reticulum lumen]
(R-HSA-8956762)
0.527
2
UniProt:Q6ZN06 ZN813
0.527
2
UniProt:P02763 ORM1
4
ORM1 [platelet alpha granule lumen]
(R-HSA-8848906)
ORM1 [specific granule lumen]
(R-HSA-6799632)
ORM1 [extracellular region]
(R-HSA-6799687)
ORM1 [tertiary granule lumen]
(R-HSA-6801026)
0.527
2
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.527
2
UniProt:P17035 ZNF28
1
ZNF28 [nucleoplasm]
(R-HSA-1027421)
0.527
2
UniProt:Q71UM5 RPS27L
2
RPS27L [nucleoplasm]
(R-HSA-6791197)
RPS27L [cytosol]
(R-HSA-8868849)
0.527
2
UniProt:P17097 ZNF7
0.527
2
UniProt:P02768 ALB
7
ALB(19-609) [extracellular region]
(R-HSA-114609)
ALB [platelet alpha granule lumen]
(R-HSA-49865)
salicyl-ALB [extracellular region]
(R-HSA-9750694)
acetyl-ALB [extracellular region]
(R-HSA-9749660)
ALB [extracellular region]
(R-HSA-194115)
p-ALB [endoplasmic reticulum lumen]
(R-HSA-8956930)
ALB [endoplasmic reticulum lumen]
(R-HSA-8956690)
0.527
2
UniProt:P01024 C3
20
C3d fragment [extracellular region]
(R-HSA-198999)
C3 alpha chain [secretory granule lumen]
(R-HSA-6800982)
C3 beta chain [secretory granule lumen]
(R-HSA-6801014)
C3 alpha chain [azurophil granule lumen]
(R-HSA-6799161)
C3 beta chain [azurophil granule lumen]
(R-HSA-6799159)
p-C3 [endoplasmic reticulum lumen]
(R-HSA-8957056)
C3 [endoplasmic reticulum lumen]
(R-HSA-8956774)
C3c alpha' chain fragment 1 precursor [extracellular region]
(R-HSA-976816)
C3c alpha' chain fragment 2 [extracellular region]
(R-HSA-976818)
C3c alpha' chain fragment 1 [extracellular region]
(R-HSA-3266502)
C3a-desArg [extracellular region]
(R-HSA-8852808)
C3dg [plasma membrane]
(R-HSA-3266505)
C3d [plasma membrane]
(R-HSA-8853248)
C3f [extracellular region]
(R-HSA-976779)
C3 beta chain [plasma membrane]
(R-HSA-977593)
C3c alpha' chain fragment 1 precursor [plasma membrane]
(R-HSA-977595)
C3c alpha' chain fragment 2 [plasma membrane]
(R-HSA-977594)
C3 alpha chain [extracellular region]
(R-HSA-166820)
C3b alpha' [extracellular region]
(R-HSA-166830)
C3 beta chain [extracellular region]
(R-HSA-166821)
0.527
2
UniProt:P12504 VIF
0.499
2
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