Reactome | TP53BP1 recruits DCLRE1C to ATM

TP53BP1 recruits DCLRE1C to ATM

Stable Identifier

R-HSA-5686900

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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TP53BP1 is required for the recruitment of DCLRE1C (ARTEMIS) to DNA double strand breaks (DSBs) and ATM-mediated phosphorylation of DCLRE1C (Riballo et al. 2004). DCRLE1C directly interacts with the TP53BP1-binding protein PAX1IP (PTIP) (Wang et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
15574327	A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci Recio, MJ, Löbrich, M, Kühne, M, Jackson, SP, Parker, AR, Doherty, A, Dahm, K, Rief, N, Riballo, E, Smith, GC, Fricke, A, Gennery, A, Jeggo, PA, Reis, C, Krempler, A	Mol. Cell	2004
25512557	PTIP associates with Artemis to dictate DNA repair pathway choice Lobrich, M, Aroumougame, A, Gong, Z, Chen, J, Chen, D, Li, Y, Wang, J	Genes Dev.	2014