TP53BP1 recruits DCLRE1C to ATM

Stable Identifier
R-HSA-5686900
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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TP53BP1 is required for the recruitment of DCLRE1C (ARTEMIS) to DNA double strand breaks (DSBs) and ATM-mediated phosphorylation of DCLRE1C (Riballo et al. 2004). DCRLE1C directly interacts with the TP53BP1-binding protein PAX1IP (PTIP) (Wang et al. 2014).

Literature References
PubMed ID Title Journal Year
15574327 A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci

Recio, MJ, Löbrich, M, Kühne, M, Jackson, SP, Parker, AR, Doherty, A, Dahm, K, Rief, N, Riballo, E, Smith, GC, Fricke, A, Gennery, A, Jeggo, PA, Reis, C, Krempler, A

Mol. Cell 2004
25512557 PTIP associates with Artemis to dictate DNA repair pathway choice

Lobrich, M, Aroumougame, A, Gong, Z, Chen, J, Chen, D, Li, Y, Wang, J

Genes Dev. 2014
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