Reactome | SLX1A [nucleoplasm]

SLX1A [nucleoplasm]

Stable Identifier

R-HSA-5686481

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Structure-specific endonuclease subunit SLX1, SLX1, SLX1B, GIYD2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BQ83 SLX1A

Gene Names

SLX1A, GIYD1, SLX1, SLX1B, GIYD2, SLX1

Chain

chain:1-275

Reference Genes

BioGPS Gene:548593 SLX1A

BioGPS Gene:79008 SLX1A

COSMIC (genes):SLX1A SLX1A

CTD Gene:548593 SLX1A

CTD Gene:79008 SLX1A

dbSNP Gene:548593 SLX1A

dbSNP Gene:79008 SLX1A

ENSEMBL:ENSG00000132207 SLX1A

ENSEMBL:ENSG00000181625 SLX1A

ENSEMBL_homo_sapiens_GENE:ENSG00000132207.18 SLX1A

ENSEMBL_homo_sapiens_GENE:ENSG00000181625.18 SLX1A

HGNC:20922 SLX1A

HGNC:28748 SLX1A

KEGG Gene (Homo sapiens):548593 SLX1A

KEGG Gene (Homo sapiens):79008 SLX1A

Monarch:548593 SLX1A

Monarch:79008 SLX1A

NCBI Gene:548593 SLX1A

NCBI Gene:79008 SLX1A

OMIM:615822 SLX1A

OMIM:615823 SLX1A

UCSC:Q9BQ83 SLX1A

Reference Transcript

Other Identifiers

11722692_x_at

11742399_s_at

130134321

218317_PM_x_at

218317_x_at

233334_PM_x_at

233334_x_at

3655451

3655452

3655455

3655457

3655459

3655460

3655462

3655463

3655464

3656033

3656034

3656037

3656039

3656041

3656042

3656044

3656045

3656046

548593

64454_at

79008

80466_s_at

A_23_P501451

GE82771

GO:0000228

GO:0000724

GO:0003824

GO:0004518

GO:0004519

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006310

GO:0006974

GO:0008821

GO:0010792

GO:0010833

GO:0016787

GO:0017108

GO:0032200

GO:0033557

GO:0043226

GO:0046872

GO:0061820

GO:0090656

GO:0140097

GO:1904357

GO:1904431

HMNXSV003019181

ILMN_1656382

ILMN_1664993

ILMN_1670517

ILMN_1703894

ILMN_2262177

ILMN_2272708

ILMN_2368575

g13129003_3p_a_at

g13129003_3p_s_at

Participates

as a component of

SLX1A:SLX4 [nucleoplasm] (Homo sapiens)

Inferred To

slx1 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SLX1A [nucleoplasm] (Gallus gallus)

SLX1A [nucleoplasm] (Bos taurus)

SLX1A [nucleoplasm] (Canis familiaris)

SLX1A [nucleoplasm] (Sus scrofa)

Slx1b [nucleoplasm] (Mus musculus)

Slx1b [nucleoplasm] (Rattus norvegicus)

slx1a [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001014999.1, NP_076949.1, NP_001015000.1, NP_835145.1

OpenTargets

ENSG00000132207

GeneCards

Q9BQ83

HPA

ENSG00000181625-SLX1B, ENSG00000132207-SLX1A

Ensembl

ENSP00000251303, ENSP00000328940, ENSP00000335316, ENST00000345535, ENSP00000333945, ENSG00000181625, ENSG00000132207, ENST00000351581, ENST00000330181, ENST00000251303

PRO

Q9BQ83

Pharos - Targets

Q9BQ83

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92889 ERCC4	1	ERCC4 [nucleoplasm] (R-HSA-67445)	0.564	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.527	2
UniProt:Q96NY9 MUS81	1	MUS81 [nucleoplasm] (R-HSA-5686443)	0.527	2
UniProt:P07992 ERCC1	2	Ub-ERCC1 [nucleoplasm] (R-HSA-5696473) ERCC1 [nucleoplasm] (R-HSA-54427)	0.527	2
UniProt:P27540 ARNT	1	ARNT [nucleoplasm] (R-HSA-1234098)	0.527	2
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	2
UniProt:O14867 BACH1	5	BACH1 [nucleoplasm] (R-HSA-9707688) BACH1 [cytosol] (R-HSA-9708429) PolyUb-BACH1 [nucleoplasm] (R-HSA-9708486) p-Y483 BACH1 [nucleoplasm] (R-HSA-9762202) p-Y483 BACH1 [cytosol] (R-HSA-9762206)	0.527	2