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SLX4 [nucleoplasm]
Stable Identifier
R-HSA-5686477
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Structure-specific endonuclease subunit SLX4, BTB/POZ domain-containing protein 12, BTBD12
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Resolution of D-Loop Structures (Homo sapiens)
Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
SLX1A:SLX4:MUS81:EME1,(MUS81:EME2),GEN1 [nucleoplasm] (Homo sapiens)
SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
SLX1A:SLX4 [nucleoplasm] (Homo sapiens)
SLX4 [nucleoplasm] (Homo sapiens)
SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)
SLX1A:SLX4 [nucleoplasm] (Homo sapiens)
SLX4 [nucleoplasm] (Homo sapiens)
SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
SLX1A:SLX4 [nucleoplasm] (Homo sapiens)
SLX4 [nucleoplasm] (Homo sapiens)
Fanconi Anemia Pathway (Homo sapiens)
DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
SLX1A:SLX4 [nucleoplasm] (Homo sapiens)
SLX4 [nucleoplasm] (Homo sapiens)
SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
SLX1A:SLX4 [nucleoplasm] (Homo sapiens)
SLX4 [nucleoplasm] (Homo sapiens)
DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
SLX1A:SLX4 [nucleoplasm] (Homo sapiens)
SLX4 [nucleoplasm] (Homo sapiens)
SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
SLX1A:SLX4 [nucleoplasm] (Homo sapiens)
SLX4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IY92 SLX4
Gene Names
SLX4, BTBD12, KIAA1784, KIAA1987
Chain
chain:1-1834
Reference Genes
BioGPS Gene:84464 SLX4
COSMIC (genes):SLX4 SLX4
CTD Gene:84464 SLX4
dbSNP Gene:84464 SLX4
ENSEMBL:ENSG00000188827.11 SLX4
HGNC:23845 SLX4
KEGG Gene (Homo sapiens):84464 SLX4
Monarch:84464 SLX4
NCBI Gene:84464 SLX4
OMIM:613278 SLX4
UCSC:Q8IY92 SLX4
Reference Transcript
RefSeq:NM_032444.3 SLX4
Other Identifiers
0005860717
11737079_a_at
16823393
232147_PM_at
232147_at
239687_PM_at
239687_at
3677703
3677704
3677705
3677706
3677707
3677710
3677711
3677712
3677713
3677714
3677715
3677716
3677717
3677718
3677719
3677720
3677721
3677722
3677723
3677724
3677725
3677727
3677728
3677730
3677731
3677733
3677734
3677736
3677738
3677739
3677740
3677741
3677742
3677743
54507_at
75453_at
7999008
84464
A_23_P371129
GE84639
GO:0000228
GO:0000706
GO:0000712
GO:0000724
GO:0000781
GO:0000785
GO:0003677
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006259
GO:0006260
GO:0006281
GO:0006289
GO:0006310
GO:0006974
GO:0006996
GO:0007059
GO:0008047
GO:0010792
GO:0019899
GO:0022414
GO:0030054
GO:0032200
GO:0032206
GO:0032991
GO:0033557
GO:0036297
GO:0043226
GO:0046872
GO:0048476
GO:0050790
GO:0061820
GO:0070522
GO:0072429
GO:0090656
GO:0098772
GO:0140013
GO:1904357
GO:1904431
HMNXSV003056608
Hs.143681.0.A1_3p_at
Hs.143681.0.A1_3p_x_at
Hs.98026.0.S1_3p_s_at
ILMN_1732885
PH_hs_0005371
PH_hs_0031801
TC16000821.hg
Participates
as a component of
SLX1A:SLX4 [nucleoplasm] (Homo sapiens)
Inferred To
slx4 [nucleoplasm]
(Xenopus tropicalis)
Slx4 [nucleoplasm]
(Rattus norvegicus)
SLX4 [nucleoplasm]
(Bos taurus)
SLX4 [nucleoplasm]
(Canis familiaris)
SLX4 [nucleoplasm]
(Danio rerio)
SLX4 [nucleoplasm]
(Gallus gallus)
SLX4 [nucleoplasm]
(Mus musculus)
SLX4 [nucleoplasm]
(Sus scrofa)
mus312 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_115820.2
OpenTargets
ENSG00000188827
HPA
ENSG00000188827-SLX4
GeneCards
Q8IY92
Ensembl
ENSG00000188827
,
ENST00000294008
,
ENSP00000294008
PRO
Q8IY92
Pharos - Targets
Q8IY92
Orphanet
19826
PDB
4ZOU
,
4UYI
,
4M7C
,
7BU5
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96NY9 MUS81
1
MUS81 [nucleoplasm]
(R-HSA-5686443)
0.845
13
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.777
8
UniProt:Q92889 ERCC4
1
ERCC4 [nucleoplasm]
(R-HSA-67445)
0.725
10
UniProt:P07992 ERCC1
2
Ub-ERCC1 [nucleoplasm]
(R-HSA-5696473)
ERCC1 [nucleoplasm]
(R-HSA-54427)
0.641
6
UniProt:P43246 MSH2
3
MSH2 [nucleoplasm]
(R-HSA-5357525)
MSH2 GLN601TER [nucleoplasm]
(R-HSA-5577243)
MSH2 R406* [nucleoplasm]
(R-HSA-5575594)
0.567
5
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