SLX1A (SLX1) and SLX4 constitutively form a heterodimeric endonucleolytic complex that possesses a robust Holliday junction resolvase activity (Fekairi et al. 2009). SLX1A:SLX4 can form a complex with the MUS81:EME1 (and likely MUS81:EME2) complex, named SLX-MUS, through direct interaction of SLX4 with MUS81 (Fekairi et al. 2009, Wyatt et al. 2013). SLX-MUS is a more efficient and coordinated resolvase of Holliday junctions than SLX1A:SLX4 or MUS81:EME1 (or MUS81:EME2) (Wyatt et al. 2013).
West, SC, Matos, J, Sarbajna, S, Wyatt, HD
Yates, JR, Coulon, S, Ruse, C, Fekairi, S, Russell, P, McGowan, CH, Tissier, A, Gaillard, PH, Taylor, ER, Dong, MQ, Chahwan, C, Fuchs, RP, Scaglione, S
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