SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)

Stable Identifier
R-HSA-5686475
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)
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SLX1A (SLX1) and SLX4 constitutively form a heterodimeric endonucleolytic complex that possesses a robust Holliday junction resolvase activity (Fekairi et al. 2009). SLX1A:SLX4 can form a complex with the MUS81:EME1 (and likely MUS81:EME2) complex, named SLX-MUS, through direct interaction of SLX4 with MUS81 (Fekairi et al. 2009, Wyatt et al. 2013). SLX-MUS is a more efficient and coordinated resolvase of Holliday junctions than SLX1A:SLX4 or MUS81:EME1 (or MUS81:EME2) (Wyatt et al. 2013).
Literature References
PubMed ID Title Journal Year
24076221 Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells

West, SC, Matos, J, Sarbajna, S, Wyatt, HD

Mol. Cell 2013
19596236 Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

Yates, JR, Coulon, S, Ruse, C, Fekairi, S, Russell, P, McGowan, CH, Tissier, A, Gaillard, PH, Taylor, ER, Dong, MQ, Chahwan, C, Fuchs, RP, Scaglione, S

Cell 2009
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Orthologous Events
SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Bos taurus)
SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Canis familiaris)
SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)
SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Rattus norvegicus)
SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Sus scrofa)
SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-04-01)
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