SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)

Stable Identifier
R-HSA-5686475
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SLX1A (SLX1) and SLX4 constitutively form a heterodimeric endonucleolytic complex that possesses a robust Holliday junction resolvase activity (Fekairi et al. 2009). SLX1A:SLX4 can form a complex with the MUS81:EME1 (and likely MUS81:EME2) complex, named SLX-MUS, through direct interaction of SLX4 with MUS81 (Fekairi et al. 2009, Wyatt et al. 2013). SLX-MUS is a more efficient and coordinated resolvase of Holliday junctions than SLX1A:SLX4 or MUS81:EME1 (or MUS81:EME2) (Wyatt et al. 2013).

Literature References
PubMed ID Title Journal Year
19596236 Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

Fekairi, S, Scaglione, S, Chahwan, C, Taylor, ER, Tissier, A, Coulon, S, Dong, MQ, Ruse, C, Yates, JR, Russell, P, Fuchs, RP, McGowan, CH, Gaillard, PH

Cell 2009
24076221 Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells

Wyatt, HD, Sarbajna, S, Matos, J, West, SC

Mol. Cell 2013
Participants
Participant Of
Orthologous Events
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