Reactome | EME2 [nucleoplasm]

EME2 [nucleoplasm]

Stable Identifier

R-HSA-5686438

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Probable crossover junction endonuclease EME2

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2),GEN1 [nucleoplasm] (Homo sapiens)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
        
        MUS81 binds EME1, EME2 (Homo sapiens)
        
        EME1,EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
        
        SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
- Fanconi Anemia Pathway (Homo sapiens)
  - DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Homo sapiens)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Homo sapiens)
        
        MUS81:EME2 [nucleoplasm] (Homo sapiens)
        
        EME2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:A4GXA9 EME2

Gene Names

EME2

Chain

chain:1-379

Reference Genes

BioGPS Gene:197342 EME2

COSMIC (genes):EME2 EME2

CTD Gene:197342 EME2

dbSNP Gene:197342 EME2

ENSEMBL:ENSG00000197774 EME2

HGNC:27289 EME2

KEGG:hsa:197342 EME2

Monarch:197342 EME2

NCBI Gene:197342 EME2

OMIM:610886 EME2

UCSC:A4GXA9 EME2

Reference Transcript

RefSeq:NM_001257370.1 EME2

Other Identifiers

11742493_a_at

11763289_at

1556024_PM_at

1556024_at

1569867_PM_at

1569867_at

1569868_PM_s_at

1569868_s_at

16814825

197342

3644143

3644144

3644146

3644147

3644148

3644149

3644150

3644151

3644152

3644153

3644154

3644155

3644156

3644157

3644158

3644159

3644160

3644161

3644163

3644164

3644165

3644166

3644167

3644168

3644169

3644170

3644171

7992379

A_14_P119765

A_14_P127316

A_23_P366125

A_33_P3297005

GO:0000712

GO:0003677

GO:0003824

GO:0004518

GO:0004519

GO:0005515

GO:0005634

GO:0006281

GO:0006302

GO:0006310

GO:0008821

GO:0016787

GO:0022414

GO:0031297

GO:0031573

GO:0043226

GO:0043596

GO:0048476

GO:0140097

GO:1905347

HMNXSV003031759

HMNXSV003053734

Hs2.362366.2.S1_3p_s_at

Hs2.436634.1.A1_3p_at

ILMN_1771185

PH_hs_0017361

PH_hs_0036421

PH_hs_0039017

TC16000047.hg

Participates

as a candidate of

EME1,EME2 [nucleoplasm] (Homo sapiens)

as a component of

MUS81:EME2 [nucleoplasm] (Homo sapiens)

Inferred To

EME2 [nucleoplasm] (Bos taurus)

EME2 [nucleoplasm] (Sus scrofa)

eme1 [nucleoplasm] (Schizosaccharomyces pombe)

eme2 [nucleoplasm] (Xenopus tropicalis)

Eme2 [nucleoplasm] (Mus musculus)

Eme2 [nucleoplasm] (Rattus norvegicus)

MMS4 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001244299.1

ENSEMBL

ENSP00000457353, ENSG00000197774, ENST00000568449

OpenTargets

ENSG00000197774

GeneCards

EME2

HPA

ENSG00000197774-EME2

PRO

A4GXA9

Pharos - Targets

A4GXA9

PDB

7F6L

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96NY9 MUS81	1	MUS81 [nucleoplasm] (R-HSA-5686443)	0.544	3