MUS81 binds EME1, EME2

Stable Identifier
R-HSA-5686430
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MUS81 binds EME1 (MMS4) to form an evolutionarily conserved endonuclease complex involved in processing of aberrant replication intermediates and the cleavage of homologous recombination intermediates (Ciccia et al. 2003, Ogrunc and Sancar 2003). MUS81 can also form an endonuclease complex with EME2. EME2 is 40% identical to EME1 at the amino acid level and the MUS81:EME2 complex likely functions in a similar way to the MUS81:EME1 complex (Ciccia et al. 2007).

Literature References
PubMed ID Title Journal Year
12686547 Identification and characterization of human MUS81-MMS4 structure-specific endonuclease

O?rünç, M, Sancar, A

J. Biol. Chem. 2003
17289582 Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM

Ciccia, A, Ling, C, Coulthard, R, Yan, Z, Xue, Y, Meetei, AR, Laghmani, el H, Joenje, H, McDonald, N, de Winter, JP, Wang, W, West, SC

Mol. Cell 2007
12721304 Identification and characterization of the human mus81-eme1 endonuclease

Ciccia, A, Constantinou, A, West, SC

J. Biol. Chem. 2003
Participants
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Orthologous Events
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