Reactome | MUS81 binds EME1, EME2

MUS81 binds EME1, EME2

Stable Identifier

R-HSA-5686430

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        MUS81 binds EME1, EME2 (Homo sapiens)

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MUS81 binds EME1 (MMS4) to form an evolutionarily conserved endonuclease complex involved in processing of aberrant replication intermediates and the cleavage of homologous recombination intermediates (Ciccia et al. 2003, Ogrunc and Sancar 2003). MUS81 can also form an endonuclease complex with EME2. EME2 is 40% identical to EME1 at the amino acid level and the MUS81:EME2 complex likely functions in a similar way to the MUS81:EME1 complex (Ciccia et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17289582	Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM Ciccia, A, Ling, C, Coulthard, R, Yan, Z, Xue, Y, Meetei, AR, Laghmani, el H, Joenje, H, McDonald, N, de Winter, JP, Wang, W, West, SC	Mol. Cell	2007
12686547	Identification and characterization of human MUS81-MMS4 structure-specific endonuclease O?rünç, M, Sancar, A	J. Biol. Chem.	2003
12721304	Identification and characterization of the human mus81-eme1 endonuclease Ciccia, A, Constantinou, A, West, SC	J. Biol. Chem.	2003