Reactome | SPIDR binds BLM:TOP3A:RMI1:RMI2

SPIDR binds BLM:TOP3A:RMI1:RMI2

Stable Identifier

R-HSA-5686398

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)

General

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SPIDR binds the BTRR complex (BLM:TOP3A:RMI1:RMI2) through a direct interaction with BLM. SPIDR also interacts with RAD51, thereby connecting the BTRR complex with Holliday Junctions (Wan et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23509288	Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair Wan, L, Han, J, Liu, T, Dong, S, Xie, F, Chen, H, Huang, J	Proc. Natl. Acad. Sci. U.S.A.	2013