SFTPs translocate from extracellular region to clathrin-coated vesicle

Stable Identifier
R-HSA-5686359
Type
Reaction [dissociation]
Species
Homo sapiens
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Surfactant catabolism by alveolar macrophages plays a small but critical part in surfactant recycling and metabolism. Upon ligand binding, granulocyte-macrophage colony-stimulating factor receptor (GM-CSF), a heterodimer of alpha (CSF2RA) and beta (CSF2RB) subunits (Hansen et al. 2008), initiates a signalling process that not only induces proliferation, differentiation and functional activation of hematopoietic cells but can also determine surfactant uptake into alveolar macrophages and its degradation via clathrin-coated vesicles. The exact mechanism of surfactant degradation in macrophages is poorly understood (Jain et al. 2005, Ikegami 2006). GM-CSF-deficiency can result in pulmonary alveolar proteinosis (PAP), a lung disease characterised by surfactant accumulation and lipid-engorged alveolar macrophages (Carey & Trapnell 2010).

Literature References
PubMed ID Title Journal Year
16006481 Pathways for clearance of surfactant protein A from the lung

Jain, D, Dodia, C, Fisher, AB, Bates, SR

Am. J. Physiol. Lung Cell Mol. Physiol. 2005
16423266 Surfactant catabolism

Ikegami, M

Respirology 2006
20338813 The molecular basis of pulmonary alveolar proteinosis

Carey, B, Trapnell, BC

Clin. Immunol. 2010
18692472 The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

Hansen, G, Hercus, TR, McClure, BJ, Stomski, FC, Dottore, M, Powell, J, Ramshaw, H, Woodcock, JM, Xu, Y, Guthridge, M, McKinstry, WJ, Lopez, AF, Parker, MW

Cell 2008
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