Reactome | SFTPs translocate from extracellular region to clathrin-coated vesicle

SFTPs translocate from extracellular region to clathrin-coated vesicle

Stable Identifier

R-HSA-5686359

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region, clathrin-coated endocytic vesicle

ReviewStatus

5/5

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SFTPs translocate from extracellular region to clathrin-coated vesicle

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Surfactant catabolism by alveolar macrophages plays a small but critical part in surfactant recycling and metabolism. Upon ligand binding, granulocyte-macrophage colony-stimulating factor receptor (GM-CSF), a heterodimer of alpha (CSF2RA) and beta (CSF2RB) subunits (Hansen et al. 2008), initiates a signalling process that not only induces proliferation, differentiation and functional activation of hematopoietic cells but can also determine surfactant uptake into alveolar macrophages and its degradation via clathrin-coated vesicles. The exact mechanism of surfactant degradation in macrophages is poorly understood (Jain et al. 2005, Ikegami 2006). GM-CSF-deficiency can result in pulmonary alveolar proteinosis (PAP), a lung disease characterised by surfactant accumulation and lipid-engorged alveolar macrophages (Carey & Trapnell 2010).

Literature References

PubMed ID	Title	Journal	Year
16423266	Surfactant catabolism Ikegami, M	Respirology	2006
16006481	Pathways for clearance of surfactant protein A from the lung Jain, D, Dodia, C, Fisher, AB, Bates, SR	Am. J. Physiol. Lung Cell Mol. Physiol.	2005
20338813	The molecular basis of pulmonary alveolar proteinosis Carey, B, Trapnell, BC	Clin. Immunol.	2010
18692472	The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation Hansen, G, Hercus, TR, McClure, BJ, Stomski, FC, Dottore, M, Powell, J, Ramshaw, H, Woodcock, JM, Xu, Y, Guthridge, M, McKinstry, WJ, Lopez, AF, Parker, MW	Cell	2008