Reactome | ZDHHC2 transfers PALM from PALM-CoA to CKAP4

ZDHHC2 transfers PALM from PALM-CoA to CKAP4

Stable Identifier

R-HSA-5686304

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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ZDHHC2 transfers PALM from PALM-CoA to CKAP4

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The palmitoyltransferase ZDHHC2 transfers a palmitoyl group (PALM) from the high energy donor palmitoyl-CoA (PALM-CoA) to cytoskeleton-associated protein 4 (CKAP4 aka p63). CKAP4 is thought to be a surfactant A binding protein on the surface of alveolar type II epithelial cells where it plays a role in bridging the plasma membrane to the cytoskeleton and in the reuptake of surfactant A. CKAP4 palmitoylation on the cysteine 100 residue by DHHC2 is required for its trafficking from the ER to the plasma membrane (Schweizer et al. 1993, Planey et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
8314870	A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein DeMaio, A, Schweizer, A, Hauri, HP, Jenö, P, Rohrer, J, Buchman, TG	J. Cell. Sci.	1993
19144824	Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling Keay, SK, Zacharias, DA, Zhang, CO, Planey, SL	Mol. Biol. Cell	2009