ZDHHC2 transfers PALM from PALM-CoA to CKAP4

Stable Identifier
R-HSA-5686304
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The palmitoyltransferase ZDHHC2 transfers a palmitoyl group (PALM) from the high energy donor palmitoyl-CoA (PALM-CoA) to cytoskeleton-associated protein 4 (CKAP4 aka p63). CKAP4 is thought to be a surfactant A binding protein on the surface of alveolar type II epithelial cells where it plays a role in bridging the plasma membrane to the cytoskeleton and in the reuptake of surfactant A. CKAP4 palmitoylation on the cysteine 100 residue by DHHC2 is required for its trafficking from the ER to the plasma membrane (Schweizer et al. 1993, Planey et al. 2009).

Literature References
PubMed ID Title Journal Year
19144824 Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling

Planey, SL, Keay, SK, Zhang, CO, Zacharias, DA

Mol. Biol. Cell 2009
8314870 A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein

Schweizer, A, Rohrer, J, Jenö, P, DeMaio, A, Buchman, TG, Hauri, HP

J. Cell. Sci. 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
palmitoyltransferase activity of ZDHHC2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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