PALM-C100-CKAP4 binds SFTPAs

Stable Identifier
R-HSA-5686301
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Alveolar surfactant is cleared by distinct pathways. Surfactant proteins (SFTPs) are reutilised by type II cells that internalise alveolar phospholipids destined for re-incorporation into LB for secretion. Alternatively, intra-alveolar or extracellular surfactant is degraded. A substantial portion of surfactant is reutilised (25-95%) in type II cells, promoted by SFTPA (the most abundant surfactant protein) via interaction with a high-affinity receptor present on the cell surface. A candidate for the SFTPA receptor detected on type II epithelial cells is cytoskeleton-associated protein 4 (CKAP4 aka p63), a reversibly palmitoylated transmembrane protein (PALM-C100-CKAP4), initially identified in the ER and Golgi apparatus (Bates 2010).

Literature References
PubMed ID Title Journal Year
20054143 P63 (CKAP4) as an SP-A receptor: implications for surfactant turnover

Bates, SR

Cell. Physiol. Biochem. 2010
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