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PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body
Stable Identifier
R-HSA-5686286
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
,
lamellar body
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Surfactant metabolism (Homo sapiens)
PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Homo sapiens)
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Alveolar surfactant is cleared by distinct pathways. Surfactant proteins (SFTPs) are reutilised by type II cells that internalise alveolar phospholipids destined for re-incorporation into LB for secretion or intra-alveolar or extracellular surfactant is degraded. A substantial portion of surfactant is reutilised (25-95%) in type II cells, promoted by SFTPA (the most abundant surfactant protein) via interaction with a high-affinity receptor present on the cell surface. A candidate for the SFTPA receptor detected on type II epithelial cells is cytoskeleton-associated protein 4 (CKAP4 aka p63), a reversibly palmitoylated transmembrane protein (PALM-C100-CKAP4), initially identified in the ER and Golgi apparatus (Bates 2010). SFTPA and CKAP4 seem to enter the cell as a unit since both are found in early endosomes. At what point SFTPA and CKAP4 separate or whether CKAP4 chaperones SFTPA to the lamellar body is currently unknown. The receptors for the other surfactant proteins (SFTPB, C, D) that are also recycled are not yet identified.
Literature References
PubMed ID
Title
Journal
Year
20054143
P63 (CKAP4) as an SP-A receptor: implications for surfactant turnover
Bates, SR
Cell. Physiol. Biochem.
2010
Participants
Input
PALM-C100-CKAP4:SFTPAs [plasma membrane]
(Homo sapiens)
Output
PALM-C100-CKAP4:SFTPAs [lamellar body]
(Homo sapiens)
Participates
as an event of
Surfactant metabolism (Homo sapiens)
Orthologous Events
PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Bos taurus)
PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Canis familiaris)
PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Danio rerio)
PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Gallus gallus)
PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Mus musculus)
PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Rattus norvegicus)
Authored
Jassal, B (2015-04-01)
Reviewed
D'Eustachio, P (2015-08-17)
Created
Jassal, B (2015-04-01)
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