Reactome | RMI2 [nucleoplasm]

RMI2 [nucleoplasm]

Stable Identifier

R-HSA-5685951

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RecQ-mediated genome instability protein 2, BLAP18, BLM-associated protein of 18 kDa

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - G2/M DNA damage checkpoint (Homo sapiens)
      - ATR phosphorylates TP53 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        D-loop extension by DNA polymerases (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        CX3 complex binds D-loop structures (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        BCDX2 complex stabilizes RAD51 filament (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        BLM mediates dissolution of double Holliday junction (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) (Homo sapiens)
        
        D-loop dissociation and strand annealing (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
      - HDR through Single Strand Annealing (SSA) (Homo sapiens)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        ATR activation at DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        ATR phosphorylates RPA2 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Homo sapiens)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of DNA repair (Homo sapiens)
  - Diseases of DNA Double-Strand Break Repair (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to BRCA1 loss of function (Homo sapiens)
      - Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
        
        Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
      - Impaired BRCA2 binding to PALB2 (Homo sapiens)
        
        Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:BRCA2 mutants (PALB2 binding):SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
      - Impaired BRCA2 binding to RAD51 (Homo sapiens)
        
        BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to PALB2 loss of function (Homo sapiens)
      - Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function (Homo sapiens)
        
        Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)
      - Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function (Homo sapiens)
        
        Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        ATR phosphorylates TP53 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Homo sapiens)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)
        
        RMI2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96E14 RMI2

Gene Names

RMI2, C16orf75

Chain

initiator methionine:1, chain:2-147

Reference Genes

BioGPS Gene:116028 RMI2

COSMIC (genes):RMI2 RMI2

CTD Gene:116028 RMI2

dbSNP Gene:116028 RMI2

ENSEMBL:ENSG00000175643.10 RMI2

HGNC:28349 RMI2

KEGG Gene (Homo sapiens):116028 RMI2

Monarch:116028 RMI2

NCBI Gene:116028 RMI2

OMIM:612426 RMI2

UCSC:Q96E14 RMI2

Reference Transcript

RefSeq:NM_152308.2 RMI2

Other Identifiers

116028

11744297_a_at

16815905

226456_PM_at

226456_at

3648248

3648255

3648257

3648260

3648263

3648264

3648265

3648266

3648267

3648268

3648269

7993248

ADDON002853.hg

A_14_P132665

GE788423

GO:0000724

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006260

GO:0006281

GO:0006310

GO:0007059

GO:0016607

GO:0031422

GO:0033045

GO:0043007

GO:0043226

GO:0071139

GO:2000042

Hs.77448.2.S1_3p_at

ILMN_1790537

PH_hs_0016741

TC16000160.hg

Participates

as a component of

BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of RMI2 [nucleoplasm] (Caenorhabditis elegans)

Rmi2 [nucleoplasm] (Mus musculus)

rmi2 [nucleoplasm] (Danio rerio)

rmi2 [nucleoplasm] (Xenopus tropicalis)

RMI2 [nucleoplasm] (Bos taurus)

RMI2 [nucleoplasm] (Canis familiaris)

RMI2 [nucleoplasm] (Dictyostelium discoideum)

RMI2 [nucleoplasm] (Gallus gallus)

RMI2 [nucleoplasm] (Rattus norvegicus)

RMI2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_689521.1

OpenTargets

ENSG00000175643

HPA

ENSG00000175643-RMI2

GeneCards

Q96E14

Ensembl

ENST00000312499, ENSG00000175643, ENST00000572173, ENSP00000310356, ENSP00000461206

PRO

Q96E14

Pharos - Targets

Q96E14

Orphanet

27164

PDB

3NBH, 4DAY, 3MXN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54132 BLM	2	4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883) BLM [nucleoplasm] (R-HSA-174881)	0.723	5
UniProt:Q14159 SPIDR	1	SPIDR [nucleoplasm] (R-HSA-5686408)	0.462	2

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