Reactome | CX3 complex binds D-loop structures

CX3 complex binds D-loop structures

Stable Identifier

R-HSA-5685838

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        CX3 complex binds D-loop structures (Homo sapiens)

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The CX3 complex, composed of RAD51 paralogs RAD51C and XRCC3 (Masson, Tarsounas et al. 2001), binds homologous recombination repair sites at a later time point than the BCDX2 complex (Chun et al. 2013). Both RAD51C and XRCC3 can directly interact with PALB2 (Park et al. 2014). CX3 complexes, as well as BCDX2 complexes, multimerize into ring like structures with a central cavity (Masson, Stasiak et al. 2001, Compton et al. 2010). The CX3 complex may be involved in the resolution of Holliday junctions (Liu et al. 2004, Liu et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
14716019	RAD51C is required for Holliday junction processing in mammalian cells West, SC, Shah, R, O'Regan, P, Masson, JY, Liu, Y	Science	2004
11459987	Complex formation by the human RAD51C and XRCC3 recombination repair proteins Benson, FE, Masson, JY, West, SC, Stasiak, AZ, Stasiak, A	Proc. Natl. Acad. Sci. U.S.A.	2001
23149936	Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway Buechelmaier, ES, Powell, SN, Chun, J	Mol. Cell. Biol.	2013
20207730	Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy Ozgür, S, Compton, SA, Griffith, JD	J. Biol. Chem.	2010
11751635	Identification and purification of two distinct complexes containing the five RAD51 paralogs Benson, FE, Shah, R, Masson, JY, West, SC, Stasiak, AZ, Tarsounas, MC, Stasiak, A, McIlwraith, MJ	Genes Dev.	2001
24141787	Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair Park, JY, Nassar, N, Freund, M, Andreassen, PR, Hanenberg, H, Meetei, AR, Singh, TR, Zhang, F	Oncogene	2014
17114795	Role of RAD51C and XRCC3 in genetic recombination and DNA repair West, SC, O'Regan, P, Liu, Y, Tarsounas, M	J. Biol. Chem.	2007