CX3 complex binds D-loop structures

Stable Identifier
R-HSA-5685838
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The CX3 complex, composed of RAD51 paralogs RAD51C and XRCC3 (Masson, Tarsounas et al. 2001), binds homologous recombination repair sites at a later time point than the BCDX2 complex (Chun et al. 2013). Both RAD51C and XRCC3 can directly interact with PALB2 (Park et al. 2014). CX3 complexes, as well as BCDX2 complexes, multimerize into ring like structures with a central cavity (Masson, Stasiak et al. 2001, Compton et al. 2010). The CX3 complex may be involved in the resolution of Holliday junctions (Liu et al. 2004, Liu et al. 2007).

Literature References
PubMed ID Title Journal Year
11459987 Complex formation by the human RAD51C and XRCC3 recombination repair proteins

Masson, JY, Stasiak, AZ, Stasiak, A, Benson, FE, West, SC

Proc. Natl. Acad. Sci. U.S.A. 2001
14716019 RAD51C is required for Holliday junction processing in mammalian cells

Liu, Y, Masson, JY, Shah, R, O'Regan, P, West, SC

Science 2004
23149936 Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway

Chun, J, Buechelmaier, ES, Powell, SN

Mol. Cell. Biol. 2013
20207730 Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy

Compton, SA, Ozg├╝r, S, Griffith, JD

J. Biol. Chem. 2010
11751635 Identification and purification of two distinct complexes containing the five RAD51 paralogs

Masson, JY, Tarsounas, MC, Stasiak, AZ, Stasiak, A, Shah, R, McIlwraith, MJ, Benson, FE, West, SC

Genes Dev. 2001
24141787 Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

Park, JY, Singh, TR, Nassar, N, Zhang, F, Freund, M, Hanenberg, H, Meetei, AR, Andreassen, PR

Oncogene 2014
17114795 Role of RAD51C and XRCC3 in genetic recombination and DNA repair

Liu, Y, Tarsounas, M, O'Regan, P, West, SC

J. Biol. Chem. 2007
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