Reactome | TRAPPC6B [cytosol]

TRAPPC6B [cytosol]

Stable Identifier

R-HSA-5685735

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
  - Rab regulation of trafficking (Homo sapiens)
    - RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
      - TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)
        
        TRAPPCs [cytosol] (Homo sapiens)
        
        TRAPPCII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)
        
        TRAPPCIII [cytosol] (Homo sapiens)
        
        TRAPPC6B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86SZ2 TRAPPC6B

Gene Names

TRAPPC6B

Chain

chain:1-158

Reference Genes

BioGPS Gene:122553 TRAPPC6B

COSMIC (genes):TRAPPC6B TRAPPC6B

CTD Gene:122553 TRAPPC6B

dbSNP Gene:122553 TRAPPC6B

ENSEMBL:ENSG00000182400 TRAPPC6B

ENSEMBL_homo_sapiens_GENE:ENSG00000182400.15 TRAPPC6B

HGNC:23066 TRAPPC6B

KEGG Gene (Homo sapiens):122553 TRAPPC6B

Monarch:122553 TRAPPC6B

NCBI Gene:122553 TRAPPC6B

OMIM:610397 TRAPPC6B

UCSC:Q86SZ2 TRAPPC6B

Reference Transcript

Other Identifiers

11720257_a_at

11720258_a_at

122553

16792268

225537_PM_at

225537_at

3562007

3562008

3562009

3562010

3562011

3562014

3562015

3562016

3562019

3562023

3562024

48521_at

77473_at

7978739

83471_r_at

90605_at

A_24_P304581

A_24_P942132

GE80128

GO:0005515

GO:0005737

GO:0005768

GO:0005783

GO:0005794

GO:0005801

GO:0005802

GO:0005829

GO:0006888

GO:0006901

GO:0007399

GO:0016192

GO:0030008

GO:0031410

GO:0043087

GO:0043226

GO:0048193

GO:0048856

GO:0061024

GO:0099022

GO:1990071

HMNXSV003037316

Hs.13303.0.S1_3p_at

ILMN_1666007

ILMN_2272967

ILMN_2369104

PH_hs_0001281

TC14001064.hg

Participates

as a component of

Inferred To

Trs33 [cytosol] (Drosophila melanogaster)

TRAPPC6B [cytosol] (Bos taurus)

TRAPPC6B [cytosol] (Canis familiaris)

TRAPPC6B [cytosol] (Dictyostelium discoideum)

TRAPPC6B [cytosol] (Plasmodium falciparum)

TRAPPC6B [cytosol] (Schizosaccharomyces pombe)

TRAPPC6B [cytosol] (Sus scrofa)

TRAPPC6A [cytosol] (Gallus gallus)

TRS33 [cytosol] (Saccharomyces cerevisiae)

trpp-6 [cytosol] (Caenorhabditis elegans)

trappc6b [cytosol] (Danio rerio)

Trappc6b [cytosol] (Mus musculus)

Trappc6b [cytosol] (Rattus norvegicus)

Ghost homologue of TRAPPC6B [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_803235.1, NP_001073005.1

OpenTargets

ENSG00000182400

GeneCards

Q86SZ2

HPA

ENSG00000182400-TRAPPC6B

Ensembl

ENSP00000335171, ENST00000330149, ENST00000347691, ENSP00000330289, ENSG00000182400

PRO

Q86SZ2

Pharos - Targets

Q86SZ2

Orphanet

28721

PDB

3KXC, 2BJN, 2CFH

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BZR8 BCL2L14	1	BCL2L14 [cytosol] (R-HSA-6791317)	0.643	4
UniProt:Q9P2M4 TBC1D14	1	TBC1D14 [recycling endosome] (R-HSA-8854764)	0.527	2

Cite Us!