Reactome | CLEC2B binds KLRF1 dimer

CLEC2B binds KLRF1 dimer

Stable Identifier

R-HSA-5685608

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CLEC2B binds CLEC5C dimer

ReviewStatus

5/5

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Killer cell lectin-like receptor subfamily F member 1 (KLRF1 also referred as NKp80 or CLEC5C) is a homodimeric C-type lectin receptor (CTLR) expressed virtually on all human NK cells, and a minor subsets of effector memory CD8 alpha/beta T cells and gamma/delta T cells (Vitale et al. 2001). NKp80 binds to the genetically linked receptor C-type lectin domain family 2 member B (CLEC2B also referred as AICL) (Welte et al. 2006). CLEC2B is expressed as a myeloid-specific activating receptor that is upregulated by Toll-like receptor stimulation (Hamann et al. 1997). NKp80-CLEC2B interaction triggers NK cell-mediated cytolysis of malignant myeloid cells. Crosslinking of both NKp80 and CLEC2B was shown to promote an activating cross-talk between NK cells and monocytes in the presence of inflammatory cytokines (Welte et al. 2006, Klimosch et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23929856	Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses Klimosch, SN, Steinle, A, Bartel, Y, Wiemann, S	Blood	2013
11265639	Identification of NKp80, a novel triggering molecule expressed by human NK cells Bottino, C, Moretta, A, Moretta, L, Biassoni, R, Semenzato, G, Falco, M, Zambello, R, Parolini, S, Castriconi, R, Vitale, M	Eur. J. Immunol.	2001
17057721	Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction Waldhauer, I, Steinle, A, Welte, S, Kuttruff, S	Nat. Immunol.	2006