Reactome | Sialic acid binds SIGLEC

Sialic acid binds SIGLEC

Stable Identifier

R-HSA-5685607

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Sialic acid binding immunoglobulins (Ig)-like lectins (SIGLECs) belong to I-type lectin with a selective expression on the haematopoetic cell lineages. These have amazing structural diversity each recognizing differently linked terminal sialic acid on glycoproteins and glycolipids expressed on host cells as well as pathogen (Powell & Varki 1995, Crocker 2002). Fifteen human SIGLECs have been identified so far. Interaction with various sialylated glycoconjugates, SIGLECs undertake various functions such as internalization of sialylated pathogens, attenuation of inflammation, restraining cellular activation, attenuation of damage-associated molecular pattern-mediated in?ammation along with inhibition of NK cell activation (von Gunten & Bochner 2008, Pillai et al. 2012, Matthew et al. 2014). The sialic acid-binding Ig-like lectins CD33 (SIGLEC3), SIGLEC7 and -9 are inhibitory receptors expressed on human NK cells and subsets of peripheral T cells that recognise sialic acid-containing carbohydrates (Hernández-Caselles et al. 2006, Falco et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
16380601	A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing Hernández-Caselles, T, Martínez-Esparza, M, Pérez-Oliva, AB, Quintanilla-Cecconi, AM, García-Alonso, A, Alvarez-López, DM, García-Peñarrubia, P	J. Leukoc. Biol.	2006
16014749	Siglecs--the major subfamily of I-type lectins Varki, A, Angata, T	Glycobiology	2006
10499918	Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells Falco, M, Biassoni, R, Bottino, C, Vitale, M, Sivori, S, Augugliaro, R, Moretta, L, Moretta, A	J. Exp. Med.	1999