SLAMF6 binds SLAMF6

Stable Identifier
R-HSA-5685604
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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SLAMF6 binds SLAMF6
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Members of the signaling lymphocytic-activation molecule (SLAM) family, are all encoded in the SLAM locus, and are mostly homotypic self-associating receptors expressed by cells of hemopoietic origin (Veillette et al. 2006). SLAMF6 (also called as NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses (Cao et al. 2006).

Literature References
PubMed ID Title Journal Year
18031695 Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development

Griewank, K, Borowski, C, Rietdijk, S, Wang, N, Julien, A, Wei, DG, Mamchak, AA, Terhorst, C, Bendelac, A

Immunity 2007
17045824 NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family

Cao, E, Ramagopal, UA, Fedorov, A, Fedorov, E, Yan, Q, Lary, JW, Cole, JL, Nathenson, SG, Almo, SC

Immunity 2006
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Orthologous Events
SLAMF6 binds SLAMF6 (Bos taurus)
SLAMF6 binds SLAMF6 (Canis familiaris)
SLAMF6 binds SLAMF6 (Danio rerio)
SLAMF6 binds SLAMF6 (Gallus gallus)
SLAMF6 binds SLAMF6 (Mus musculus)
SLAMF6 binds SLAMF6 (Rattus norvegicus)
SLAMF6 binds SLAMF6 (Sus scrofa)
Authored
Garapati, P V  (2015-03-27)
Reviewed
Barrow, AD  (2015-05-13)
Created
Garapati, P V  (2015-03-27)