Reactome | SLAMF6 binds SLAMF6

SLAMF6 binds SLAMF6

Stable Identifier

R-HSA-5685604

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Members of the signaling lymphocytic-activation molecule (SLAM) family, are all encoded in the SLAM locus, and are mostly homotypic self-associating receptors expressed by cells of hemopoietic origin (Veillette et al. 2006). SLAMF6 (also called as NTB-A) is a homophilic receptor that stimulates cytotoxicity in natural killer (NK) cells, regulates bactericidal activities in neutrophils, and potentiates T helper 2 (Th2) responses (Cao et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
17045824	NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family Cao, E, Ramagopal, UA, Fedorov, A, Fedorov, E, Yan, Q, Lary, JW, Cole, JL, Nathenson, SG, Almo, SC	Immunity	2006
18031695	Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development Griewank, K, Borowski, C, Rietdijk, S, Wang, N, Julien, A, Wei, DG, Mamchak, AA, Terhorst, C, Bendelac, A	Immunity	2007