Reactome | NCR3LG1 binds NCR3

NCR3LG1 binds NCR3

Stable Identifier

R-HSA-5685602

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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NCR3 (NKp30) is one of the natural cytotoxicity receptors (NCRs) expressed mainly on the surface of the natural killer (NK) cells. NKp30 is a major receptor targeting virus-infected cells, malignantly transformed cells, and immature dendritic cells. NCR3 (NKp30) recognizes tumor antigens B7H6, a member of the B7 family (Kaifu et al. 2011, Brandt et al. 2009). B7H6 is not expressed normally, and is found on tumor cells, and sensitizes targets to NCR3-dependent cytotoxicity by NK cells.

Literature References

PubMed ID	Title	Journal	Year
24305946	BAG-6, a jack of all trades in health and disease Binici, J, Koch, J	Cell. Mol. Life Sci.	2014
21877119	B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumors Kaifu, T, Escalière, B, Gastinel, LN, Vivier, E, Baratin, M	Cell. Mol. Life Sci.	2011
18055229	Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells Pogge von Strandmann, E, Simhadri, VR, von Tresckow, B, Sasse, S, Reiners, KS, Hansen, HP, Rothe, A, Böll, B, Simhadri, VL, Borchmann, P, McKinnon, PJ, Hallek, M, Engert, A	Immunity	2007