viral HA binds NCRI

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Influenza A virus, Sendai virus
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Natural killer (NK) cells express a multitude of activating and inactivating cell surface receptors through which they recognise tumors and infected cells. Among the activating receptors, the family of Ig-like molecules is termed natural cytotoxicity receptors (NCRs). These NCRs include Natural cytotoxicity triggering receptor 1 (NCR1 also referred as NKp46 or LY94), Natural cytotoxicity triggering receptor 2 (NCR2 also referred as NKp44) and Natural cytotoxicity triggering receptor 3 (NCR3 also referred as NKp30 ) (Hecht et al. 2009). All three NCRs are involved in the elimination of both tumor and virus infected cells. NCRs are coupled to different signal transducing adaptor proteins, including CD3zeta, FCER1G, and KARAP/DAP12.
NCR1 (NKp46) is selectively expressed by all resting and activated human NK cells (Sivori et al. 1997). NCRI recognises and targets the direct killing of virus-infected cells. The antiviral activity is initiated by the interaction of NCR1 with hemagglutinin of influenza virus or Sendai virus (Mandelboim et al. 2001). Biochemical analysis revealed that NCR1 molecules are coupled with associated adaptor proteins CD3z and FCERIG that contain immune tyrosine-based activating motifs (ITAM) (Moretta et al. 2001).
Literature References
PubMed ID Title Journal Year
9314561 p46, a novel natural killer cell-specific surface molecule that mediates cell activation

Bottino, C, Sivori, S, Moretta, A, Moretta, L, Morelli, L, Sanseverino, L, Augugliaro, R, Vitale, M

J. Exp. Med. 1997
9730896 Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity

Bottino, C, Sivori, S, Moretta, A, Moretta, L, Morelli, L, Biassoni, R, Malaspina, A, Pessino, A

J. Exp. Med. 1998
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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