Reactome | CX3 complex formation

CX3 complex formation

Stable Identifier

R-HSA-5685319

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        CX3 complex formation (Homo sapiens)

General

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RAD51 paralogs RAD51C and XRCC3 form the CX3 complex with 1:1 stoichiometry (Masson et al. 2001, Chun et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23149936	Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway Buechelmaier, ES, Powell, SN, Chun, J	Mol. Cell. Biol.	2013
11751635	Identification and purification of two distinct complexes containing the five RAD51 paralogs Benson, FE, Shah, R, Masson, JY, West, SC, Stasiak, AZ, Tarsounas, MC, Stasiak, A, McIlwraith, MJ	Genes Dev.	2001