Reactome | BCDX2 complex formation

BCDX2 complex formation

Stable Identifier

R-HSA-5685318

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        BCDX2 complex formation (Homo sapiens)

General

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RAD51 paralogs RAD51B, RAD51C, RAD51D and XRCC2 form a complex named BCDX2 with 1:1:1:1 stoichiometry. In this complex, RAD51B directly interacts with RAD51C, which interacts with RAD51D, which interacts with XRCC2 (Masson et al. 2001, Chun et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
11751635	Identification and purification of two distinct complexes containing the five RAD51 paralogs Masson, JY, Tarsounas, MC, Stasiak, AZ, Stasiak, A, Shah, R, McIlwraith, MJ, Benson, FE, West, SC	Genes Dev.	2001
23149936	Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway Chun, J, Buechelmaier, ES, Powell, SN	Mol. Cell. Biol.	2013