SFTPD gene produces SFTPD protein

Stable Identifier
R-HSA-5685290
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human gene SFTPD produces pulmonary surfactant-associated protein D. The final processed product is a 12mer consisting of four sets of SFTPD trimer (Rust et al. 1991, Lu et al. 1992, Hakansson et al. 1999). It is secreted into the pulmonary alveoli. In addition to its surfactant-related functions, SFTPD, like SFTPA, contributes to the lung's defense against inhaled pathogens and allergens by binding and clearing these entities from the lung (Lu et al. 1992, Crouch et al. 1993) (not annotated here).

Literature References
PubMed ID Title Journal Year
10368295 Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D

HÃ¥kansson, K, Lim, NK, Hoppe, HJ, Reid, KB

Structure 1999
1339284 Purification, characterization and cDNA cloning of human lung surfactant protein D

Lu, J, Willis, AC, Reid, KB

Biochem. J. 1992
8428971 Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1

Crouch, E, Rust, K, Veile, R, Donis-Keller, H, Grosso, L

J. Biol. Chem. 1993
1898081 Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain

Rust, K, Grosso, L, Zhang, V, Chang, D, Persson, A, Longmore, W, Cai, GZ, Crouch, E

Arch. Biochem. Biophys. 1991
Participants
Participant Of
Authored
Reviewed
Created
Cite Us!