Reactome | SFTPD gene produces SFTPD protein

SFTPD gene produces SFTPD protein

Stable Identifier

R-HSA-5685290

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, endoplasmic reticulum membrane

ReviewStatus

5/5

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The human gene SFTPD produces pulmonary surfactant-associated protein D. The final processed product is a 12mer consisting of four sets of SFTPD trimer (Rust et al. 1991, Lu et al. 1992, Hakansson et al. 1999). It is secreted into the pulmonary alveoli. In addition to its surfactant-related functions, SFTPD, like SFTPA, contributes to the lung's defense against inhaled pathogens and allergens by binding and clearing these entities from the lung (Lu et al. 1992, Crouch et al. 1993) (not annotated here).

Literature References

PubMed ID	Title	Journal	Year
1339284	Purification, characterization and cDNA cloning of human lung surfactant protein D Reid, KB, Lu, J, Willis, AC	Biochem. J.	1992
10368295	Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D Lim, NK, Hoppe, HJ, Reid, KB, Håkansson, K	Structure	1999
8428971	Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1 Donis-Keller, H, Grosso, L, Rust, K, Veile, R, Crouch, E	J. Biol. Chem.	1993
1898081	Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain Grosso, L, Chang, D, Zhang, V, Rust, K, Longmore, W, Persson, A, Cai, GZ, Crouch, E	Arch. Biochem. Biophys.	1991