CCDC59:TTF1 binds SFTPB gene

Stable Identifier
R-HSA-5685208
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Surfactant proteins B (SFTPB) is a small hydrophobic surfactant protein that maintains surface tension in alveoli. In the nucleus, SFTPB is regulated by a key factor, transcription termination factor 1 (TTF1), bound to thyroid transcription factor 1-associated protein 26 (CCDC59 aka TAP26, BR22), to enhance TTF1-transactivated SFTPB promoter activity (Whitsett & Glasser 1998, Yang et al. 2006).

Literature References
PubMed ID Title Journal Year
9813380 Regulation of surfactant protein gene transcription

Whitsett, JA, Glasser, SW

Biochim. Biophys. Acta 1998
16630564 The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells

Yang, MC, Guo, Y, Liu, CC, Weissler, JC, Yang, YS

Biochem. Biophys. Res. Commun. 2006
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