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CCDC59:TTF1 binds SFTPB gene
Stable Identifier
R-HSA-5685208
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Surfactant metabolism (Homo sapiens)
CCDC59:TTF1 binds SFTPB gene (Homo sapiens)
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Surfactant proteins B (SFTPB) is a small hydrophobic surfactant protein that maintains surface tension in alveoli. In the nucleus, SFTPB is regulated by a key factor, transcription termination factor 1 (TTF1), bound to thyroid transcription factor 1-associated protein 26 (CCDC59 aka TAP26, BR22), to enhance TTF1-transactivated SFTPB promoter activity (Whitsett & Glasser 1998, Yang et al. 2006).
Literature References
PubMed ID
Title
Journal
Year
16630564
The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells
Guo, Y
,
Weissler, JC
,
Yang, YS
,
Yang, MC
,
Liu, CC
Biochem. Biophys. Res. Commun.
2006
9813380
Regulation of surfactant protein gene transcription
Glasser, SW
,
Whitsett, JA
Biochim. Biophys. Acta
1998
Participants
Input
CCDC59:TTF1 [nucleoplasm]
(Homo sapiens)
SFTPB gene [nucleoplasm]
(Homo sapiens)
Output
CCDC59:TTF1:SFTPB gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Surfactant metabolism (Homo sapiens)
Authored
Jassal, B (2015-03-26)
Reviewed
D'Eustachio, P (2015-08-17)
Created
Jassal, B (2015-03-26)
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