CCDC59:TTF1 binds SFTPC gene

Stable Identifier
Reaction [binding]
Homo sapiens
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Surfactant protein C (SFTPC) is a small hydrophobic surfactant protein that maintains surface tension in alveoli. In the nucleus, SFTPC is regulated by a key factor, transcription termination factor 1 (TTF1), bound to thyroid transcription factor 1-associated protein 26 (CCDC59 aka TAP26, BR22), to enhance TTF1-transactivated SFTPC promoter activity (Kelly et al. 1996, Whitsett & Glasser 1998, Yang et al. 2006).

Literature References
PubMed ID Title Journal Year
9813380 Regulation of surfactant protein gene transcription

Whitsett, JA, Glasser, SW

Biochim. Biophys. Acta 1998
16630564 The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells

Yang, MC, Guo, Y, Liu, CC, Weissler, JC, Yang, YS

Biochem. Biophys. Res. Commun. 2006
8636114 Transcription of the lung-specific surfactant protein C gene is mediated by thyroid transcription factor 1

Kelly, SE, Bachurski, CJ, Burhans, MS, Glasser, SW

J. Biol. Chem. 1996
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