Reactome | NAPSA, CTSH, PGA3-5 cleave pro-SFTPB

NAPSA, CTSH, PGA3-5 cleave pro-SFTPB

Stable Identifier

R-HSA-5684864

Type

Reaction [transition]

Species

Homo sapiens

Compartment

multivesicular body lumen

ReviewStatus

5/5

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In the multivesicular body, surfactant precursor protein pro-SFTPB is most likely proteolytically cleaved by napsin-A (NAPSA), cathepsin-H (CTSH) and pepsinogens 3-5 (PGA3-5) (Chuman et al. 1999, Fuchs & Gassen 1989, Athauda et al. 1989, Johansson et al. 1992). The resultant mature peptide SFTPB (chain 201-279) forms a dimeric, disulfide-linked protein (Johansson et al. 1992) and is trafficked to lamellar bodies.

Literature References

PubMed ID	Title	Journal	Year
2515193	A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins Takahashi, K, Kageyama, T, Athauda, SB, Tanji, M	J. Biochem.	1989
2587265	Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase Gassen, HG, Fuchs, R	Nucleic Acids Res.	1989
1568474	Human surfactant polypeptide SP-B. Disulfide bridges, C-terminal end, and peptide analysis of the airway form Johansson, J, Jörnvall, H, Curstedt, T	FEBS Lett.	1992
10580105	Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas Arnott, D, Ueno, T, Saito, S, Bergman, T, Appella, E, Bergman, A, Auer, G, Sakaguchi, K, Chuman, Y, Alaiya, AA, Jörnvall, H, Linder, S, Franzén, B	FEBS Lett.	1999