In the multivesicular body, surfactant precursor protein pro-SFTPB is most likely proteolytically cleaved by napsin-A (NAPSA), cathepsin-H (CTSH) and pepsinogens 3-5 (PGA3-5) (Chuman et al. 1999, Fuchs & Gassen 1989, Athauda et al. 1989, Johansson et al. 1992). The resultant mature peptide SFTPB (chain 201-279) forms a dimeric, disulfide-linked protein (Johansson et al. 1992) and is trafficked to lamellar bodies.
Fuchs, R, Gassen, HG
Athauda, SB, Tanji, M, Kageyama, T, Takahashi, K
Johansson, J, Jörnvall, H, Curstedt, T
Chuman, Y, Bergman, A, Ueno, T, Saito, S, Sakaguchi, K, Alaiya, AA, Franzén, B, Bergman, T, Arnott, D, Auer, G, Appella, E, Jörnvall, H, Linder, S
peptidase activity of NAPSA, CTSH, PGA3-5 [multivesicular body lumen]
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