NAPSA, CTSH, PGA3-5 cleave pro-SFTPB

Stable Identifier
Reaction [transition]
Homo sapiens
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In the multivesicular body, surfactant precursor protein pro-SFTPB is most likely proteolytically cleaved by napsin-A (NAPSA), cathepsin-H (CTSH) and pepsinogens 3-5 (PGA3-5) (Chuman et al. 1999, Fuchs & Gassen 1989, Athauda et al. 1989, Johansson et al. 1992). The resultant mature peptide SFTPB (chain 201-279) forms a dimeric, disulfide-linked protein (Johansson et al. 1992) and is trafficked to lamellar bodies.

Literature References
PubMed ID Title Journal Year
2515193 A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins

Takahashi, K, Kageyama, T, Athauda, SB, Tanji, M

J. Biochem. 1989
2587265 Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase

Gassen, HG, Fuchs, R

Nucleic Acids Res. 1989
1568474 Human surfactant polypeptide SP-B. Disulfide bridges, C-terminal end, and peptide analysis of the airway form

Johansson, J, Jörnvall, H, Curstedt, T

FEBS Lett. 1992
10580105 Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas

Arnott, D, Ueno, T, Saito, S, Bergman, T, Appella, E, Bergman, A, Auer, G, Sakaguchi, K, Chuman, Y, Alaiya, AA, Jörnvall, H, Linder, S, Franzén, B

FEBS Lett. 1999
Catalyst Activity

peptidase activity of NAPSA, CTSH, PGA3-5 [multivesicular body lumen]

Orthologous Events
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