Reactome | SFTPB,C, PC, PG translocate from lamellar body to extracellular region

SFTPB,C, PC, PG translocate from lamellar body to extracellular region

Stable Identifier

R-HSA-5684862

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

lamellar body, extracellular region

ReviewStatus

5/5

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SFTPB,C, PC, PG translocate from lamellar body to extracellular region

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Surfactant-containing lamellar bodies (LBs) are secreted from alveolar type II cells. Regulation of this secretion process is mediated by three G protein-coupled receptor (GPCR)-mediated pathways; P2RY2 purinoreceptor pathway (Rice & Singleton 1986), beta2 adrenergic receptor (beta2AR) pathway (Dobbs & Mason 1979) and adenosine A2B pathway (Gilfillan & Rooney 1987). Activation of these GPCR pathways cause increases in second messengers, such as adenosine 3',5'-cyclic monophosphate (cAMP) or cytosolic Ca2+, and stimulation of downstream kinases such as protein kinase C that leads to surfactant secretion (Voyno-Yasenetskaya et al. 1991). The orphan receptor GPR116 can negatively mediate this secretory process as well as having a stimulatory effect on surfactant reuptake. Gpr116-deficient mice were found to have excessive secretion and accumulation of surfactant in their airspaces after birth (Yang et al. 2013, Bridges et al. 2013, Fukuzawa et al. 2013, Liebscher et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
3801783	P2-purinoceptors regulate surfactant secretion from rat isolated alveolar type II cells Rice, WR, Singleton, FM	Br. J. Pharmacol.	1986
23684610	Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116 Floros, J, Burks, CM, Umstead, TM, Chroneos, ZC, Nagashima, K, Seaman, S, Brown, HA, Haines, DC, Ivanova, PT, Tessarollo, L, St Croix, B, Yang, MY, Hilton, MB	Cell Rep	2013
25424900	New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors Araç, D, Talbot, WS, Wolfrum, U, Liebscher, I, Prömel, S, Giera, S, Song, H, Hartmann, N, Hall, RA, Ariestanti, DM, Sigoillot, SM, Schiöth, HB, Lin, HH, Bridges, JP, Bista, BR, Duman, JG, Luo, R, Hamann, J, Ackley, B, Liu, M, Mogha, A, Monk, KR, Piao, X, Aust, G, Goffinet, AM, Tall, GG, Bae, BI, Engel, FB, Peeters, MC, White, JP, Ressl, S, Xu, L	Ann. N. Y. Acad. Sci.	2014
3037072	Functional evidence for adenosine A2 receptor regulation of phosphatidylcholine secretion in cultured type II pneumocytes Gilfillan, AM, Rooney, SA	J. Pharmacol. Exp. Ther.	1987
1928448	Regulation of ATP-dependent surfactant secretion and activation of second-messenger systems in alveolar type II cells Voyno-Yasenetskaya, TA, Dobbs, LG, Williams, MC	Am. J. Physiol.	1991
23922714	Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D Suzuki, T, Fukuzawa, T, Wakana, S, Nakamura, N, Fukamizu, A, Abe, J, Ariestanti, DM, Kato, A, Hirose, S, Takahashi, T, Ichinose, T, Ishida, J, Ito, K	PLoS ONE	2013
23590306	Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size Kinzel, B, Sato, A, Whitsett, JA, Mueller, M, Ikegami, M, Bridges, JP, Ludwig, MG, Xu, Y	Am. J. Respir. Cell Mol. Biol.	2013
34631	Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation Dobbs, LG, Mason, RJ	J. Clin. Invest.	1979