SFTPB,C, PC, PG translocate from lamellar body to extracellular region.

Stable Identifier
R-HSA-5684862
Type
Reaction [omitted]
Species
Homo sapiens
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Surfactant-containing lamellar bodies (LBs) are secreted from alveolar type II cells. Regulation of this secretion process is mediated by three G protein-coupled receptor (GPCR)-mediated pathways; P2RY2 purinoreceptor pathway (Rice & Singleton 1986), beta2 adrenergic receptor (beta2AR) pathway (Dobbs & Mason 1979) and adenosine A2B pathway (Gilfillan & Rooney 1987). Activation of these GPCR pathways cause increases in second messengers, such as adenosine 3',5'-cyclic monophosphate (cAMP) or cytosolic Ca2+, and stimulation of downstream kinases such as protein kinase C that leads to surfactant secretion (Voyno-Yasenetskaya et al. 1991). The orphan receptor GPR116 can negatively mediate this secretory process as well as having a stimulatory effect on surfactant reuptake. Gpr116-deficient mice were found to have excessive secretion and accumulation of surfactant in their airspaces after birth (Yang et al. 2013, Bridges et al. 2013, Fukuzawa et al. 2013, Liebscher et al. 2014).

Literature References
PubMed ID Title Journal Year
23684610 Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116

Yang, MY, Hilton, MB, Seaman, S, Haines, DC, Nagashima, K, Burks, CM, Tessarollo, L, Ivanova, PT, Brown, HA, Umstead, TM, Floros, J, Chroneos, ZC, St Croix, B

Cell Rep 2013
3801783 P2-purinoceptors regulate surfactant secretion from rat isolated alveolar type II cells

Rice, WR, Singleton, FM

Br. J. Pharmacol. 1986
25424900 New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors

Liebscher, I, Ackley, B, Araç, D, Ariestanti, DM, Aust, G, Bae, BI, Bista, BR, Bridges, JP, Duman, JG, Engel, FB, Giera, S, Goffinet, AM, Hall, RA, Hamann, J, Hartmann, N, Lin, HH, Liu, M, Luo, R, Mogha, A, Monk, KR, Peeters, MC, Prömel, S, Ressl, S, Schiöth, HB, Sigoillot, SM, Song, H, Talbot, WS, Tall, GG, White, JP, Wolfrum, U, Xu, L, Piao, X

Ann. N. Y. Acad. Sci. 2014
3037072 Functional evidence for adenosine A2 receptor regulation of phosphatidylcholine secretion in cultured type II pneumocytes

Gilfillan, AM, Rooney, SA

J. Pharmacol. Exp. Ther. 1987
1928448 Regulation of ATP-dependent surfactant secretion and activation of second-messenger systems in alveolar type II cells

Voyno-Yasenetskaya, TA, Dobbs, LG, Williams, MC

Am. J. Physiol. 1991
23922714 Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D

Fukuzawa, T, Ishida, J, Kato, A, Ichinose, T, Ariestanti, DM, Takahashi, T, Ito, K, Abe, J, Suzuki, T, Wakana, S, Fukamizu, A, Nakamura, N, Hirose, S

PLoS ONE 2013
23590306 Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size

Bridges, JP, Ludwig, MG, Mueller, M, Kinzel, B, Sato, A, Xu, Y, Whitsett, JA, Ikegami, M

Am. J. Respir. Cell Mol. Biol. 2013
34631 Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation

Dobbs, LG, Mason, RJ

J. Clin. Invest. 1979
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