CLEC1B dimer binds PDPN

Stable Identifier
R-HSA-5684836
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CLEC1B dimer binds PDPN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
C-type lectin domain family 1 member B (CLEC1B, CLEC2) is a 32-kDa C-type lectin-like receptor that dimerizes to form the platelet receptor for the snake venom toxin rhodocytin and the endogenous lymphatic endothelial marker, podoplanin (PDPN) (Suzuki-Inoue et al. 2006, 2007, Christou et al. 2008, Watson et al. 2009). PDPN is a sialomucin-like glycoprotein with a wide tissue distribution. It is found at a high level in lung type I alveolar cells, kidney podocytes, choroid plexus epithelium, lymphatic endothelial cells and fibroblastic reticular cells within secondary lymphoid organs. PDPN is not found on vascular endothelial cells. It is up-regulated in a variety of tumors and on macrophages following lipopolysaccharide stimulation. Cells expressing PDPN or recombinant forms of its extracellular domain have been shown to induce platelet activation (Pollitt et al. 2014).
Literature References
PubMed ID Title Journal Year
17616532 Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells

Suzuki-Inoue, K, Kato, Y, Inoue, O, Kaneko, MK, Mishima, K, Yatomi, Y, Yamazaki, Y, Narimatsu, H, Ozaki, Y

J. Biol. Chem. 2007
Participants
Input
Output
Participates
as an event of
Orthologous Events
CLEC1B dimer binds PDPN (Bos taurus)
CLEC1B dimer binds PDPN (Canis familiaris)
CLEC1B dimer binds PDPN (Mus musculus)
CLEC1B dimer binds PDPN (Rattus norvegicus)
CLEC1B dimer binds PDPN (Sus scrofa)
Authored
Jupe, S  (2015-03-20)
Reviewed
Akkerman, JW  (2015-11-09)
Created
Jupe, S  (2015-03-23)
Cite Us!