CLEC1B dimer binds PDPN

Stable Identifier
Reaction [binding]
Homo sapiens
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C-type lectin domain family 1 member B (CLEC1B, CLEC2) is a 32-kDa C-type lectin-like receptor that dimerizes to form the platelet receptor for the snake venom toxin rhodocytin and the endogenous lymphatic endothelial marker, podoplanin (PDPN) (Suzuki-Inoue et al. 2006, 2007, Christou et al. 2008, Watson et al. 2009). PDPN is a sialomucin-like glycoprotein with a wide tissue distribution. It is found at a high level in lung type I alveolar cells, kidney podocytes, choroid plexus epithelium, lymphatic endothelial cells and fibroblastic reticular cells within secondary lymphoid organs. PDPN is not found on vascular endothelial cells. It is up-regulated in a variety of tumors and on macrophages following lipopolysaccharide stimulation. Cells expressing PDPN or recombinant forms of its extracellular domain have been shown to induce platelet activation (Pollitt et al. 2014).

Literature References
PubMed ID Title Journal Year
17616532 Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells

Mishima, K, Inoue, O, Suzuki-Inoue, K, Ozaki, Y, Kato, Y, Narimatsu, H, Kaneko, MK, Yatomi, Y, Yamazaki, Y

J. Biol. Chem. 2007
Orthologous Events
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