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p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
Stable Identifier
R-HSA-5684268
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Participants
components
p-S400,T290-MAP3K8 [cytosol]
(Homo sapiens)
p-S927,S932-NFKB1(1-968) [cytosol]
(Homo sapiens)
TNIP2 [cytosol]
(Homo sapiens)
Participates
as an input of
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)
as a component of
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Homo sapiens)
Inferred To
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
(Bos taurus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
(Canis familiaris)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
(Gallus gallus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
(Mus musculus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
(Rattus norvegicus)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
(Saccharomyces cerevisiae)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
(Sus scrofa)
p-S927,S932-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]
(Xenopus tropicalis)
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