IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex

Stable Identifier
R-HSA-5684267
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NFkappaB p105 protein (p105) is a precursor of the NFkappaB p50 subunit and an inhibitor of NFkappaB. The IkappaB kinase (IKK) complex phosphorylates p105 on S927 within the PEST region. TNF-alpha-induced p105 proteolysis additionally requires the phosphorylation of S932. Purified IKK (IKK1) or IKKB (IKK2) can phosphorylate both these regulatory serines in vitro.

Literature References
PubMed ID Title Journal Year
12482991 betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932

Lang, V, Janzen, J, Fischer, GZ, Soneji, Y, Beinke, S, Salmeron, A, Allen, H, Hay, RT, Ben-Neriah, Y, Ley, SC

Mol Cell Biol 2003
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Participant Of
Catalyst Activity
Catalyst Activity
Title
IkappaB kinase activity of IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created