NFkappaB p105 protein (p105) is a precursor of the NFkappaB p50 subunit and an inhibitor of NFkappaB. The IkappaB kinase (IKK) complex phosphorylates p105 on S927 within the PEST region. TNF-alpha-induced p105 proteolysis additionally requires the phosphorylation of S932. Purified IKK (IKK1) or IKKB (IKK2) can phosphorylate both these regulatory serines in vitro.
Ley, SC, Hay, RT, Janzen, J, Beinke, S, Salmeron, A, Lang, V, Fischer, GZ, Soneji, Y, Ben-Neriah, Y, Allen, H
IkappaB kinase activity of p-S177,S181-IKKB:IKKA:NEMO [cytosol]
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