LMCD1 binds GATA6, sequestering it

Stable Identifier
R-HSA-5683888
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
LMCD1 binds GATA6, sequestering it
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The GATA transcription factors regulate gene expression in a variety of cell types including cardiovascular, pulmonary and hematopoietic tissues. LIM and cysteine-rich domains protein 1 (LMCD1) is a transcriptional cofactor that binds GATA6 and thus restricts its function by inhibiting its DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes (Rath et al. 2005).
Literature References
PubMed ID Title Journal Year
16199866 LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding

Wang, Z, Morrisey, EE, Rath, N, Lu, MM

Mol. Cell. Biol. 2005
Participants
Input
Output
Participates
as an event of
Orthologous Events
LMCD1 binds GATA6, sequestering it (Bos taurus)
LMCD1 binds GATA6, sequestering it (Caenorhabditis elegans)
LMCD1 binds GATA6, sequestering it (Canis familiaris)
LMCD1 binds GATA6, sequestering it (Drosophila melanogaster)
LMCD1 binds GATA6, sequestering it (Gallus gallus)
LMCD1 binds GATA6, sequestering it (Mus musculus)
LMCD1 binds GATA6, sequestering it (Rattus norvegicus)
LMCD1 binds GATA6, sequestering it (Sus scrofa)
LMCD1 binds GATA6, sequestering it (Xenopus tropicalis)
Authored
Jassal, B  (2015-03-17)
Reviewed
D'Eustachio, P  (2015-08-17)
Created
Jassal, B  (2015-03-17)
Cite Us!