SFTPC gene produces pro-SFTPC protein

Stable Identifier
R-HSA-5683836
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
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SFTPC gene produces pro-SFTPC protein
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The human gene SFTPC produces surfactant protein C (SFTPC) (Whitsett & Glasser 1998, Kelly et al. 1996). The transcription complex transcription termination factor 1 and thyroid transcription factor 1-associated protein 26 (TTF1:CCDC59), enhances TTF1-transactivated SFTPC promoter activity.

Literature References
PubMed ID Title Journal Year
8636114 Transcription of the lung-specific surfactant protein C gene is mediated by thyroid transcription factor 1

Kelly, SE, Bachurski, CJ, Burhans, MS, Glasser, SW

J. Biol. Chem. 1996
9813380 Regulation of surfactant protein gene transcription

Whitsett, JA, Glasser, SW

Biochim. Biophys. Acta 1998
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Output
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as an event of
This event is regulated
Positively by
Regulator
CCDC59:TTF1:SFTPC gene [nucleoplasm] (Homo sapiens)
Authored
Jassal, B  (2015-03-17)
Reviewed
D'Eustachio, P  (2015-08-17)
Created
Jassal, B  (2015-03-17)
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