CCDC59 binds TTF1

Stable Identifier
R-HSA-5683831
Type
Reaction [binding]
Species
Homo sapiens
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Surfactant proteins B and C (SFTPB and C) are small hydrophobic surfactant proteins that maintain surface tension in alveoli. Both SFTPB and C are regulated by a key factor, transcription termination factor 1 (TTF1), in lung cells (Evers & Grummt 1995). Thyroid transcription factor 1-associated protein 26 (CCDC59 aka TAP26, BR22) (Yang et al. 2003) binds to TTF1 and enhances TTF1-transactivated SFTPB and C promoter activity (Yang et al. 2006).

Literature References
PubMed ID Title Journal Year
7597036 Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I.

Evers, R, Grummt, I

Proc Natl Acad Sci U S A 1995
12882447 BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells

Yang, MC, Wang, B, Weissler, JC, Margraf, LR, Yang, YS

Eur. Respir. J. 2003
16630564 The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells

Yang, MC, Guo, Y, Liu, CC, Weissler, JC, Yang, YS

Biochem. Biophys. Res. Commun. 2006
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