CCDC59 binds TTF1

Stable Identifier
Reaction [binding]
Homo sapiens
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Surfactant proteins B and C (SFTPB and C) are small hydrophobic surfactant proteins that maintain surface tension in alveoli. Both SFTPB and C are regulated by a key factor, transcription termination factor 1 (TTF1), in lung cells (Evers & Grummt 1995). Thyroid transcription factor 1-associated protein 26 (CCDC59 aka TAP26, BR22) (Yang et al. 2003) binds to TTF1 and enhances TTF1-transactivated SFTPB and C promoter activity (Yang et al. 2006).

Literature References
PubMed ID Title Journal Year
12882447 BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells

Margraf, LR, Yang, MC, Wang, B, Yang, YS, Weissler, JC

Eur. Respir. J. 2003
7597036 Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I.

Evers, R, Grummt, I

Proc Natl Acad Sci U S A 1995
16630564 The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells

Guo, Y, Weissler, JC, Yang, YS, Yang, MC, Liu, CC

Biochem. Biophys. Res. Commun. 2006
Orthologous Events
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