Reactome | CCDC59 binds TTF1

CCDC59 binds TTF1

Stable Identifier

R-HSA-5683831

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Surfactant proteins B and C (SFTPB and C) are small hydrophobic surfactant proteins that maintain surface tension in alveoli. Both SFTPB and C are regulated by a key factor, transcription termination factor 1 (TTF1), in lung cells (Evers & Grummt 1995). Thyroid transcription factor 1-associated protein 26 (CCDC59 aka TAP26, BR22) (Yang et al. 2003) binds to TTF1 and enhances TTF1-transactivated SFTPB and C promoter activity (Yang et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12882447	BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells Margraf, LR, Yang, MC, Wang, B, Yang, YS, Weissler, JC	Eur. Respir. J.	2003
7597036	Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I. Evers, R, Grummt, I	Proc Natl Acad Sci U S A	1995
16630564	The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells Guo, Y, Weissler, JC, Yang, YS, Yang, MC, Liu, CC	Biochem. Biophys. Res. Commun.	2006