Reactome | EYA1 [nucleoplasm]

EYA1 [nucleoplasm]

Stable Identifier

R-HSA-5683625

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Eyes absent homolog 1

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - ATM phosphorylates EYA1-4 (Homo sapiens)
        
        EYA1-4 [nucleoplasm] (Homo sapiens)
        
        EYA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99502 EYA1

Gene Names

EYA1

Chain

chain:1-592

Reference Genes

BioGPS Gene:2138 EYA1

COSMIC (genes):EYA1 EYA1

CTD Gene:2138 EYA1

dbSNP Gene:2138 EYA1

ENSEMBL:ENSG00000104313 EYA1

ENSEMBL_homo_sapiens_GENE:ENSG00000104313.20 EYA1

HGNC:3519 EYA1

KEGG Gene (Homo sapiens):2138 EYA1

Monarch:2138 EYA1

NCBI Gene:2138 EYA1

OMIM:601653 EYA1

UCSC:Q99502 EYA1

Reference Transcript

Other Identifiers

11733671_a_at

11741159_a_at

11741226_a_at

17078134

2138

214608_PM_s_at

214608_s_at

3140057

3140058

3140059

3140060

3140064

3140066

3140067

3140068

3140069

3140070

3140079

3140083

3140085

3140094

3140095

3140096

3140101

3140103

3140104

3140106

3140109

3140115

3140117

3140118

3140119

3140120

3140121

3140122

3140123

3140124

3140146

3140152

3140154

3140160

3140165

3140166

3140167

37073_at

8151310

A_19_P00318343

A_19_P00320476

A_19_P00322060

A_19_P00322863

A_23_P502363

A_33_P3216763

A_33_P3366667

A_33_P3368238

GE55122

GE80846

GO:0001656

GO:0001657

GO:0001658

GO:0003151

GO:0003723

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006281

GO:0006302

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006974

GO:0007275

GO:0007389

GO:0007501

GO:0007605

GO:0009653

GO:0009887

GO:0010212

GO:0012501

GO:0014706

GO:0016604

GO:0016787

GO:0016925

GO:0017018

GO:0023052

GO:0030154

GO:0032991

GO:0032993

GO:0035909

GO:0036211

GO:0042472

GO:0042473

GO:0042474

GO:0043226

GO:0045165

GO:0045664

GO:0045739

GO:0045893

GO:0045944

GO:0046872

GO:0048665

GO:0048704

GO:0048752

GO:0048856

GO:0050673

GO:0050679

GO:0050877

GO:0060037

GO:0071599

GO:0071600

GO:0072513

GO:0090103

GO:0097192

GO:0140096

GO:0140793

GO:2001240

HMNXSV003028678

HMNXSV003045517

Hs.94210.0.S2_3p_a_at

ILMN_1747207

ILMN_1807554

ILMN_2322874

PH_hs_0005167

TC08001316.hg

TC08002377.hg

Y10260_at

Participates

as a component of

as an input of

as an output of

Expression of EYA1 in metanephric mesenchyme (Homo sapiens)

as a member of

EYA1-4 [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

Expression of SIX1 in metanephric mesenchyme (Homo sapiens)

Other forms of this molecule

p-EYA1 [nucleoplasm]

Inferred To

EYA1 [nucleoplasm] (Bos taurus)

EYA1 [nucleoplasm] (Caenorhabditis elegans)

EYA1 [nucleoplasm] (Canis familiaris)

EYA1 [nucleoplasm] (Drosophila melanogaster)

EYA1 [nucleoplasm] (Gallus gallus)

EYA1 [nucleoplasm] (Mus musculus)

EYA1 [nucleoplasm] (Rattus norvegicus)

EYA1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001275504.1, XP_016868695.1, XP_016868701.1, NP_000494.2, NP_742055.1, NP_742056.1, NP_742057.1, NP_001275503.1

OpenTargets

ENSG00000104313

HPA

ENSG00000104313-EYA1

GeneCards

Q99502

Ensembl

ENSP00000494438, ENST00000645793, ENST00000647540, ENST00000340726, ENST00000419131, ENSP00000496255, ENST00000388742, ENST00000388740, ENSP00000410176, ENSP00000373392, ENSG00000104313, ENSP00000342626, ENSP00000373394

PRO

Q99502

Pharos - Targets

Q99502

Orphanet

16006

HMDB Protein

HMDBP08720

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15475 SIX1	1	SIX1 [nucleoplasm] (R-HSA-9757860)	0.666	4
UniProt:Q9NPC8 SIX2	1	SIX2 [nucleoplasm] (R-HSA-9831037)	0.527	2